• Je něco špatně v tomto záznamu ?

Lipoprotein-associated phospholipase A₂ mass level is increased in elderly subjects with type 2 diabetes mellitus

J. Fortunato, V. Bláha, J. Bis, J. Št'ásek, C. Andrýs, J. Vojáček, B. Jurašková, L. Sobotka, P. Polanský, M. Brtko,

. 2014 ; 2014 (-) : 278063.

Jazyk angličtina Země Egypt

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15008056

Grantová podpora
NT12287 MZ0 CEP - Centrální evidence projektů

OBJECTIVE. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA₂ mass between them. METHODS. 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA₂ mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. RESULTS. Lp-PLA₂ mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA₂ mass was significantly increased on the diabetic group before these interventions. CONCLUSION. Lp-PLA₂ may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA₂ in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15008056
003      
CZ-PrNML
005      
20190816090525.0
007      
ta
008      
150306s2014 ua f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2014/278063 $2 doi
035    __
$a (PubMed)24818163
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ua
100    1_
$a Fortunato, Joao $7 xx0227880 $u 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
245    10
$a Lipoprotein-associated phospholipase A₂ mass level is increased in elderly subjects with type 2 diabetes mellitus / $c J. Fortunato, V. Bláha, J. Bis, J. Št'ásek, C. Andrýs, J. Vojáček, B. Jurašková, L. Sobotka, P. Polanský, M. Brtko,
520    9_
$a OBJECTIVE. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA₂ mass between them. METHODS. 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA₂ mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure. RESULTS. Lp-PLA₂ mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA₂ mass was significantly increased on the diabetic group before these interventions. CONCLUSION. Lp-PLA₂ may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA₂ in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.
650    _2
$a 1-alkyl-2-acetylglycerofosfocholinesterasa $x krev $7 D043203
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    12
$a stárnutí $7 D000375
650    _2
$a balónková angioplastika $x škodlivé účinky $7 D000800
650    _2
$a aortální chlopeň $x chirurgie $7 D001021
650    _2
$a aortální stenóza $x komplikace $x chirurgie $x terapie $7 D001024
650    _2
$a ateroskleróza $x krev $x komplikace $x enzymologie $x patofyziologie $7 D050197
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a průřezové studie $7 D003430
650    _2
$a diabetes mellitus 2. typu $x komplikace $7 D003924
650    _2
$a diabetické angiopatie $x krev $x enzymologie $x patofyziologie $7 D003925
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a chirurgická náhrada chlopně $x škodlivé účinky $7 D019918
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a aterosklerotický plát $x etiologie $7 D058226
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    12
$a upregulace $7 D015854
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Bláha, Vladimír, $u 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $d 1964- $7 xx0002944
700    1_
$a Bis, Josef $u 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $7 xx0071045
700    1_
$a Šťásek, Josef, $u 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $d 1955- $7 xx0063485
700    1_
$a Andrýs, Ctirad $u Department of Immunology and Alergology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $7 mzk2008430528
700    1_
$a Vojáček, J $u 1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic.
700    1_
$a Jurašková, Božena, $u 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $d 1956- $7 mzk2004258479
700    1_
$a Sobotka, Luboš, $u 3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $d 1952- $7 jn20001005317
700    1_
$a Polanský, Pavel $u Department of Cardiosurgery, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $7 xx0101818
700    1_
$a Brtko, Miroslav $u Department of Cardiosurgery, University Hospital Hradec Králové, Medical Faculty, Charles University, 50005 Hradec Králové, Czech Republic. $7 xx0035884
773    0_
$w MED00181720 $t Journal of diabetes research $x 2314-6753 $g Roč. 2014, č. - (2014), s. 278063
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24818163 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150306 $b ABA008
991    __
$a 20190816090755 $b ABA008
999    __
$a ok $b bmc $g 1065329 $s 890856
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 2014 $c - $d 278063 $i 2314-6753 $m Journal of diabetes research $n J Diabetes Res $x MED00181720
GRA    __
$a NT12287 $p MZ0
LZP    __
$a Pubmed-20150306

Najít záznam

Citační ukazatele

Možnosti archivace