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The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants
BM. Porcel, F. Denoeud, F. Opperdoes, B. Noel, MA. Madoui, TC. Hammarton, MC. Field, C. Da Silva, A. Couloux, J. Poulain, M. Katinka, K. Jabbari, JM. Aury, DA. Campbell, R. Cintron, NJ. Dickens, R. Docampo, NR. Sturm, VL. Koumandou, S. Fabre, P....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2005
Free Medical Journals
od 2005
Public Library of Science (PLoS)
od 2005-07-01
PubMed Central
od 2005
Europe PubMed Central
od 2005
ProQuest Central
od 2005-07-01
Open Access Digital Library
od 2005-01-01
Open Access Digital Library
od 2005-07-01
Open Access Digital Library
od 2005-01-01
Medline Complete (EBSCOhost)
od 2005-07-01
Health & Medicine (ProQuest)
od 2005-07-01
- MeSH
- Cocos genetika parazitologie MeSH
- genom MeSH
- káva genetika parazitologie MeSH
- Kinetoplastida genetika patogenita MeSH
- lidé MeSH
- nemoci rostlin genetika parazitologie MeSH
- sekvenční analýza DNA * MeSH
- semena rostlinná parazitologie MeSH
- Trypanosomatina genetika patogenita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- Francie MeSH
Members of the family Trypanosomatidae infect many organisms, including animals, plants and humans. Plant-infecting trypanosomes are grouped under the single genus Phytomonas, failing to reflect the wide biological and pathological diversity of these protists. While some Phytomonas spp. multiply in the latex of plants, or in fruit or seeds without apparent pathogenicity, others colonize the phloem sap and afflict plants of substantial economic value, including the coffee tree, coconut and oil palms. Plant trypanosomes have not been studied extensively at the genome level, a major gap in understanding and controlling pathogenesis. We describe the genome sequences of two plant trypanosomatids, one pathogenic isolate from a Guianan coconut and one non-symptomatic isolate from Euphorbia collected in France. Although these parasites have extremely distinct pathogenic impacts, very few genes are unique to either, with the vast majority of genes shared by both isolates. Significantly, both Phytomonas spp. genomes consist essentially of single copy genes for the bulk of their metabolic enzymes, whereas other trypanosomatids e.g. Leishmania and Trypanosoma possess multiple paralogous genes or families. Indeed, comparison with other trypanosomatid genomes revealed a highly streamlined genome, encoding for a minimized metabolic system while conserving the major pathways, and with retention of a full complement of endomembrane organelles, but with no evidence for functional complexity. Identification of the metabolic genes of Phytomonas provides opportunities for establishing in vitro culturing of these fastidious parasites and new tools for the control of agricultural plant disease.
Biomedical Research Foundation Academy of Athens Athens Greece
Centre National de Recherche Scientifique UMR 8030 Evry France
CIRAD TA A 98 F Campus International de Baillarguet Montpellier France
Commissariat à l'Energie Atomique Genoscope Evry France
Department of Pathology University of Cambridge Cambridge United Kingdom
e Duve Institute Université catholique de Louvain Brussels Belgium
Faculty of Biology Technion Israel Institute of Technology Haifa Israel
The Mina and Everard Goodman Faculty of Life Sciences Bar Ilan University Ramat Gan Israel
Citace poskytuje Crossref.org
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