-
Something wrong with this record ?
The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection
J. Holaň, F. Stěpánek, P. Billot, L. Ridvan,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Calorimetry MeSH
- Crystallization MeSH
- Citric Acid chemistry MeSH
- Pharmaceutical Preparations chemistry MeSH
- Solvents chemistry MeSH
- Solubility MeSH
- Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed from agomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.
Sanofi SA 13 quai Jules Guesde Vitry Sur Seine 94403 Cedex France
Zentiva k s U kabelovny 130 22 102 00 Prague 10 Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15023281
- 003
- CZ-PrNML
- 005
- 20150730105725.0
- 007
- ta
- 008
- 150709s2014 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ejps.2014.06.017 $2 doi
- 035 __
- $a (PubMed)24995701
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Holaň, Jan $u Department of Chemical Engineering, Institute of Chemical Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva k.s., U kabelovny 130/22, 102 00 Prague 10, Czech Republic. Electronic address: holanj@vscht.cz.
- 245 14
- $a The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection / $c J. Holaň, F. Stěpánek, P. Billot, L. Ridvan,
- 520 9_
- $a Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed from agomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.
- 650 _2
- $a kalorimetrie $7 D002151
- 650 _2
- $a kyselina citronová $x chemie $7 D019343
- 650 _2
- $a krystalizace $7 D003460
- 650 _2
- $a léčivé přípravky $x chemie $7 D004364
- 650 _2
- $a rozpustnost $7 D012995
- 650 _2
- $a rozpouštědla $x chemie $7 D012997
- 650 _2
- $a teplota $7 D013696
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Stěpánek, František $u Department of Chemical Engineering, Institute of Chemical Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
- 700 1_
- $a Billot, Pascal $u Sanofi SA, 13 quai Jules Guesde, Vitry-Sur-Seine, 94403 Cedex, France.
- 700 1_
- $a Ridvan, Luděk $u Zentiva k.s., U kabelovny 130/22, 102 00 Prague 10, Czech Republic.
- 773 0_
- $w MED00001639 $t European journal of pharmaceutical sciences official journal of the European Federation for Pharmaceutical Sciences $x 1879-0720 $g Roč. 63, č. - (2014), s. 124-31
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/24995701 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150709 $b ABA008
- 991 __
- $a 20150730105813 $b ABA008
- 999 __
- $a ok $b bmc $g 1083619 $s 906274
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 63 $c - $d 124-31 $i 1879-0720 $m European journal of pharmaceutical sciences $n Eur. j. pharm. sci. (Print) $x MED00001639
- LZP __
- $a Pubmed-20150709
