• Je něco špatně v tomto záznamu ?

Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes

Ali Kalantari Hesari, Rasoul Shahrooz, Abbas Ahmadi, Hasan Malekinejad, Ehsan Saboory

. 2015 ; 13 (3) : 213-223.

Jazyk angličtina Země Česko

Typ dokumentu práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15030070

This study aimed to investigate the effect of phenylhydrazine-induced hemolytic anemia on testicular functions and protective role of crocin in mice. Forty-nine adult male mice were studied in 7 groups. The control mice received normal saline, three groups were treated with 2, 4, and 6 mg/100 g of phenylhydrazine, and three other groups received 20 mg/100 g of crocin with phenylhydrazine for 35 days. Then, the blood samples were taken to examine oxidative stress of serum, sperm samples were obtained for IVF testing, and testicle tissue samples were taken for morphological studies. Morphometric results indicated a significant reduction in TDI (tubular differentiation index), RI (repopulation index or number of type B spermatogonia), and SI (spermiogenesis index) factors, number of Sertoli and Leydig cells, and diameter of germinal epithelium in the groups receiving phenylhydrazine. Histochemical results indicated some changes in the metabolic cycle of the testicle and results of serum tests showed variations in the peroxidation of lipids and antioxidant capacity of serum. Also, hemolytic anemia significantly reduced testicular parameters and crocin minimized the resulting injuries. It can be concluded that crocin is able to neutralize the complications which are resulting from the hemolytic anemia relating to testicular parameters.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc15030070
003      
CZ-PrNML
005      
20160129105727.0
007      
ta
008      
150922s2015 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jab.2015.02.001 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Hesari, Ali Kalantari $u Department of Histology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
245    10
$a Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes / $c Ali Kalantari Hesari, Rasoul Shahrooz, Abbas Ahmadi, Hasan Malekinejad, Ehsan Saboory
504    __
$a Literatura
520    9_
$a This study aimed to investigate the effect of phenylhydrazine-induced hemolytic anemia on testicular functions and protective role of crocin in mice. Forty-nine adult male mice were studied in 7 groups. The control mice received normal saline, three groups were treated with 2, 4, and 6 mg/100 g of phenylhydrazine, and three other groups received 20 mg/100 g of crocin with phenylhydrazine for 35 days. Then, the blood samples were taken to examine oxidative stress of serum, sperm samples were obtained for IVF testing, and testicle tissue samples were taken for morphological studies. Morphometric results indicated a significant reduction in TDI (tubular differentiation index), RI (repopulation index or number of type B spermatogonia), and SI (spermiogenesis index) factors, number of Sertoli and Leydig cells, and diameter of germinal epithelium in the groups receiving phenylhydrazine. Histochemical results indicated some changes in the metabolic cycle of the testicle and results of serum tests showed variations in the peroxidation of lipids and antioxidant capacity of serum. Also, hemolytic anemia significantly reduced testicular parameters and crocin minimized the resulting injuries. It can be concluded that crocin is able to neutralize the complications which are resulting from the hemolytic anemia relating to testicular parameters.
650    12
$a fertilita $x imunologie $x účinky léků $7 D005298
650    12
$a karotenoidy $x aplikace a dávkování $x terapeutické užití $7 D002338
650    _2
$a testis $x imunologie $x účinky léků $7 D013737
650    _2
$a Leydigovy buňky $x účinky léků $7 D007985
650    _2
$a Sertoliho buňky $x účinky léků $7 D012708
650    _2
$a fenylhydraziny $x aplikace a dávkování $x škodlivé účinky $7 D010659
650    12
$a hemolytické anemie $x farmakoterapie $x chemicky indukované $x prevence a kontrola $7 D000743
650    _2
$a rozmnožování $x genetika $x imunologie $x účinky léků $7 D012098
650    _2
$a oxidační stres $x genetika $x imunologie $x účinky léků $7 D018384
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a biologie buňky $7 D003585
650    _2
$a myši $7 D051379
650    _2
$a experimenty na zvířatech $7 D032761
650    _2
$a statistika jako téma $7 D013223
650    _2
$a zvířata $7 D000818
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Shahrooz, Rasoul $u Division of Histology and Embryology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
700    1_
$a Ahmadi, Abbas $u Division of Embryology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran $7 gn_A_00002426
700    1_
$a Malekinejad, Hasan $u Division of Toxicology and Pharmacology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
700    1_
$a Saboory, Ehsan $u Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran
773    0_
$t Journal of applied biomedicine $x 1214-021X $g Roč. 13, č. 3 (2015), s. 213-223 $w MED00012667
856    41
$u https://jab.zsf.jcu.cz/pdfs/jab/2015/03/06.pdf $y plný text volně přístupný
910    __
$a ABA008 $b B 2301 $c 1249 $y 4 $z 0
990    __
$a 20150522215938 $b ABA008
991    __
$a 20160129105846 $b ABA008
999    __
$a ok $b bmc $g 1091013 $s 913165
BAS    __
$a 3
BMC    __
$a 2015 $b 13 $c 3 $d 213-223 $i 1214-021X $m Journal of Applied Biomedicine $x MED00012667
LZP    __
$c NLK184 $d 20160128 $a NLK 2015-40/dk

Najít záznam

Citační ukazatele

Možnosti archivace