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Odor identification in frontotemporal lobar degeneration subtypes
H. Magerova, M. Vyhnalek, J. Laczo, R. Andel, I. Rektorova, A. Kadlecova, M. Bojar, J. Hort,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
PubMed Central
from 2001
SAGE Publications Journals
from 1999-01-01 to 2015-12-31
ROAD: Directory of Open Access Scholarly Resources
from 2000
- MeSH
- Frontotemporal Dementia complications physiopathology MeSH
- Frontotemporal Lobar Degeneration complications physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Odorants * MeSH
- Olfaction Disorders complications physiopathology MeSH
- Primary Progressive Nonfluent Aphasia complications physiopathology MeSH
- Supranuclear Palsy, Progressive complications physiopathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Severity of Illness Index MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline.
References provided by Crossref.org
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- $a Magerova, Hana $u Department of Neurology, Memory Clinic, 2nd Faculty of Medicine and Motol University Hospital, Charles University in Prague, Prague, Czech Republic magerova.hana@gmail.com.
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- $a Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline.
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