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Variation in genomic landscape of clear cell renal cell carcinoma across Europe
G. Scelo, Y. Riazalhosseini, L. Greger, L. Letourneau, M. Gonzàlez-Porta, MB. Wozniak, M. Bourgey, P. Harnden, L. Egevad, SM. Jackson, M. Karimzadeh, M. Arseneault, P. Lepage, A. How-Kit, A. Daunay, V. Renault, H. Blanché, E. Tubacher, J....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc16000567
Online
Plný text
NLK
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
PubMed
25351205
DOI
10.1038/ncomms6135
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- fokální adheze metabolismus MeSH
- fosfatidylinositol-3-kinasy genetika MeSH
- fúzní onkogenní proteiny genetika MeSH
- genetická variace * MeSH
- genom lidský genetika MeSH
- genomika * MeSH
- karcinom z renálních buněk genetika MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace MeSH
- mutační rychlost MeSH
- regulace genové exprese u nádorů MeSH
- sekvenční analýza DNA MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sestřih RNA genetika MeSH
- signální transdukce genetika MeSH
- stanovení celkové genové exprese MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. Our findings support previous reports on frequent aberrations in the epigenetic machinery and PI3K/mTOR signalling, and uncover novel pathways and genes affected by recurrent mutations and abnormal transcriptome patterns including focal adhesion, components of extracellular matrix (ECM) and genes encoding FAT cadherins. Furthermore, a large majority of patients from Romania have an unexpected high frequency of A:T>T:A transversions, consistent with exposure to aristolochic acid (AA). These results show that the processes underlying ccRCC tumorigenesis may vary in different populations and suggest that AA may be an important ccRCC carcinogen in Romania, a finding with major public health implications.
Centre 'Bioengineering' The Russian Academy of Sciences Moscow 117312 Russian Federation
Centre National de Génotypage CEA Institute de Génomique 2 rue Gaston Crémieux 91000 Evry France
Department of Pathology Karolinska Institutet SE 171 77 Stockholm Sweden
International Agency for Research on Cancer 150 cours Albert Thomas 69008 Lyon France
National Institute of Public Health Dr Leonte Anastasievici 1 3 sector 5 Bucuresti 050463 Romania
National Research Centre 'Kurchatov Institute' 1 Akademika Kurchatova pl Moscow 123182 Russia
Russian N N Blokhin Cancer Research Centre Kashirskoye shosse 24 Moscow 115478 Russian Federation
University Hospital Motol 5 Úvalu 84 150 06 Prague Czech Republic
Citace poskytuje Crossref.org
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