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Seroprevalence of Epstein-Barr Virus, Cytomegalovirus, and Polyomaviruses in Children with Inflammatory Bowel Disease
O. Hradsky, I. Copova, K. Zarubova, M. Durilova, J. Nevoral, M. Maminak, P. Hubacek, J. Bronsky,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
E-resources NLK Online Full text
ProQuest Central from 1997-01-01 to 1 year agoMedline Complete (EBSCOhost) from 2009-07-01 to 1 year ago
Nursing & Allied Health Database (ProQuest) from 1997-01-01 to 1 year ago
Health & Medicine (ProQuest) from 1997-01-01 to 1 year ago
Family Health Database (ProQuest) from 1997-01-01 to 1 year ago
Links
PubMed
26091801
DOI
10.1007/s10620-015-3764-z
Knihovny.cz E-resources
- MeSH
- Azathioprine adverse effects MeSH
- Crohn Disease diagnosis drug therapy epidemiology immunology MeSH
- Cytomegalovirus Infections diagnosis epidemiology immunology virology MeSH
- Child MeSH
- Immunocompromised Host MeSH
- Immunosuppressive Agents adverse effects MeSH
- Epstein-Barr Virus Infections diagnosis epidemiology immunology virology MeSH
- Infliximab adverse effects MeSH
- Humans MeSH
- Logistic Models MeSH
- Adolescent MeSH
- Multivariate Analysis MeSH
- Odds Ratio MeSH
- Opportunistic Infections diagnosis epidemiology immunology virology MeSH
- Polyomavirus Infections diagnosis epidemiology immunology virology MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Cross-Sectional Studies MeSH
- Risk Factors MeSH
- Seroepidemiologic Studies MeSH
- Serologic Tests MeSH
- Colitis, Ulcerative diagnosis drug therapy epidemiology immunology MeSH
- Age Factors MeSH
- Viral Load MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
BACKGROUND: Young age and thiopurine therapy are risk factors for lymphoproliferative disease among patients with inflammatory bowel disease (IBD). AIMS: The aims of this study were to evaluate the prevalence of seropositivity for the Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) among children and adolescents with IBD, to assess the viral load of EBV, CMV, and BK and JC polyomaviruses (BKV, JCV) in these patients, and to assess the influence of different therapeutic regimens on seroprevalence and viral load. METHODS: Children who had been followed in our center were tested for EBV, CMV, BKV, and JCV in a cross-sectional study. One hundred and six children were included who had Crohn's disease (68%), ulcerative colitis (29%), and unclassified IBD (3%). RESULTS: We found that 64% of patients were EBV seropositive. The proportion of EBV seropositive patients increased during childhood. Azathioprine therapy (p = 0.003) was associated with EBV seropositivity in a multiple logistic regression model, after adjusting for gender, age, and disease activity at determination. We found a significant association between the number of polymerase chain reaction copies and infliximab dose (p = 0.023). We did not find any significant association between CMV serology and CMV, BKV, or JCV viral load, or any other therapeutic regimen or clinical characteristics. CONCLUSIONS: Treatment with azathioprine appears to be a risk factor for early EBV seropositivity in children with IBD, and the infliximab dose was associated with a higher EBV viral load.
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- $a Hradsky, Ondrej $u Department of Pediatrics, University Hospital Motol and Second Faculty of Medicine, Charles University in Prague, V Uvalu 84, Prague 5, 150 06, Czech Republic. ondrej.hradsky@lfmotol.cuni.cz.
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- $a BACKGROUND: Young age and thiopurine therapy are risk factors for lymphoproliferative disease among patients with inflammatory bowel disease (IBD). AIMS: The aims of this study were to evaluate the prevalence of seropositivity for the Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) among children and adolescents with IBD, to assess the viral load of EBV, CMV, and BK and JC polyomaviruses (BKV, JCV) in these patients, and to assess the influence of different therapeutic regimens on seroprevalence and viral load. METHODS: Children who had been followed in our center were tested for EBV, CMV, BKV, and JCV in a cross-sectional study. One hundred and six children were included who had Crohn's disease (68%), ulcerative colitis (29%), and unclassified IBD (3%). RESULTS: We found that 64% of patients were EBV seropositive. The proportion of EBV seropositive patients increased during childhood. Azathioprine therapy (p = 0.003) was associated with EBV seropositivity in a multiple logistic regression model, after adjusting for gender, age, and disease activity at determination. We found a significant association between the number of polymerase chain reaction copies and infliximab dose (p = 0.023). We did not find any significant association between CMV serology and CMV, BKV, or JCV viral load, or any other therapeutic regimen or clinical characteristics. CONCLUSIONS: Treatment with azathioprine appears to be a risk factor for early EBV seropositivity in children with IBD, and the infliximab dose was associated with a higher EBV viral load.
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