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The relationship between amniotic epithelial cells and their microenvironment
Katarzyna Kopaczka, Katarzyna Skowron, Emanuel Kolanko, Piotr Czekaj
Jazyk angličtina Země Česko
Typ dokumentu přehledy
- MeSH
- amnion * anatomie a histologie cytologie embryologie MeSH
- biomedicínský výzkum MeSH
- epitelové buňky cytologie enzymologie imunologie MeSH
- extracelulární matrix enzymologie fyziologie imunologie MeSH
- faktory růstu hematopoetických buněk genetika imunologie účinky léků MeSH
- imunomodulace * imunologie MeSH
- imunosupresivní léčba MeSH
- kmenové buňky cytologie enzymologie imunologie MeSH
- lidé MeSH
- mezenchymální kmenové buňky cytologie enzymologie imunologie MeSH
- plodová voda cytologie enzymologie MeSH
- regenerativní lékařství * metody trendy MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Human amniotic epithelial cells (hAEC) are characterized by a great ability to differentiate, and immunomodulatory properties toward mother's immune system cells. These features have been described as being able to change during pregnancy. Thanks to their unique properties: low immunogenicity and high effectiveness of transplantations, amniotic epithelial cells constitute a very attractive source of stem cells for practical purposes in regenerative medicine and transplantology. In this review, we focus on natural factors potentially determining hAEC immunophenotype during pregnancy. Recognition of the impact of specific factors on hAEC would help in effective isolation, creation of appropriate culture conditions and regulation of desired cell function. We also indicate immunomodulatory properties of hAEC themselves. Discovering relations of hAEC with the microenvironment seems to be crucial for their clinical application.
Citace poskytuje Crossref.org
Literatura
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- $a Human amniotic epithelial cells (hAEC) are characterized by a great ability to differentiate, and immunomodulatory properties toward mother's immune system cells. These features have been described as being able to change during pregnancy. Thanks to their unique properties: low immunogenicity and high effectiveness of transplantations, amniotic epithelial cells constitute a very attractive source of stem cells for practical purposes in regenerative medicine and transplantology. In this review, we focus on natural factors potentially determining hAEC immunophenotype during pregnancy. Recognition of the impact of specific factors on hAEC would help in effective isolation, creation of appropriate culture conditions and regulation of desired cell function. We also indicate immunomodulatory properties of hAEC themselves. Discovering relations of hAEC with the microenvironment seems to be crucial for their clinical application.
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