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The relationship between amniotic epithelial cells and their microenvironment
Katarzyna Kopaczka, Katarzyna Skowron, Emanuel Kolanko, Piotr Czekaj
Language English Country Czech Republic
Document type Review
- MeSH
- Amnion * anatomy & histology cytology embryology MeSH
- Biomedical Research MeSH
- Epithelial Cells cytology enzymology immunology MeSH
- Extracellular Matrix enzymology physiology immunology MeSH
- Hematopoietic Cell Growth Factors genetics immunology drug effects MeSH
- Immunomodulation * immunology MeSH
- Immunosuppression Therapy MeSH
- Stem Cells cytology enzymology immunology MeSH
- Humans MeSH
- Mesenchymal Stem Cells cytology enzymology immunology MeSH
- Amniotic Fluid cytology enzymology MeSH
- Regenerative Medicine * methods trends MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Human amniotic epithelial cells (hAEC) are characterized by a great ability to differentiate, and immunomodulatory properties toward mother's immune system cells. These features have been described as being able to change during pregnancy. Thanks to their unique properties: low immunogenicity and high effectiveness of transplantations, amniotic epithelial cells constitute a very attractive source of stem cells for practical purposes in regenerative medicine and transplantology. In this review, we focus on natural factors potentially determining hAEC immunophenotype during pregnancy. Recognition of the impact of specific factors on hAEC would help in effective isolation, creation of appropriate culture conditions and regulation of desired cell function. We also indicate immunomodulatory properties of hAEC themselves. Discovering relations of hAEC with the microenvironment seems to be crucial for their clinical application.
References provided by Crossref.org
Literatura
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- $a Kopaczka, Katarzyna $u Department of Cytophysiology, Chair of Histology and Embryology, School of Medicine in Katowice, Medical University of Silesia, Medyków 18, 40-758 Katowice, Poland
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- $a Human amniotic epithelial cells (hAEC) are characterized by a great ability to differentiate, and immunomodulatory properties toward mother's immune system cells. These features have been described as being able to change during pregnancy. Thanks to their unique properties: low immunogenicity and high effectiveness of transplantations, amniotic epithelial cells constitute a very attractive source of stem cells for practical purposes in regenerative medicine and transplantology. In this review, we focus on natural factors potentially determining hAEC immunophenotype during pregnancy. Recognition of the impact of specific factors on hAEC would help in effective isolation, creation of appropriate culture conditions and regulation of desired cell function. We also indicate immunomodulatory properties of hAEC themselves. Discovering relations of hAEC with the microenvironment seems to be crucial for their clinical application.
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