Ginger and turmeric rhizomes are used in folk medicine for the treatment of several cerebrovascular diseases with limited scientific basis for their action. Hence, in this study, we investigate the effects of two Zingiberaceae varieties (ginger and turmeric) on ectonucleotidases (NTPDase and 5′-nucleotidase), adenosine deaminase (ADA) and acetylcholinesterase (AChE) activities in synaptosomes of cerebral cortex from l-NAME induced hypertensive rats. The animals were divided into seven groups (n = 10): normotensive control rats; hypertensive rats; hypertensive rats treated with atenolol; normotensive and hypertensive rats treated with 4% supplementation of turmeric and ginger rhizomes, respectively. After 14 days of pre-treatment with both rhizomes the animals were induced with hypertension by oral administration of l-NAME. The results revealed an increase of ATP and AMP hydrolysis as well as ADA and AChE activities of cerebral cortex synaptosomes in induced rats when compared with the control. The supplementation of both rhizomes prevented these alterations by decreasing ATP and AMP hydrolysis and ADA and AChE activities in cerebral cortex. In conclusion, this study demonstrated that both rhizomes interfere with the purinergic and cholinergic neurotransmission in cerebral cortex of hypertensive rats. Therefore, we can suggest that both rhizomes exert neuroprotective potential under hypertensive state.

Department of Biochemistry Afe Babalola University Ado Ekiti Private Mail Bag 5454 Nigeria

Functional Foods and Nutraceuticals Unit Department of Biochemistry Federal University of Technology Akure Private Mail Bag 704 Akure 340001 Nigeria

Health Basic Sciences Institute Department of Physiology Federal University of Rio Grande do Sul Porto Alegre RS Brazil

Programa de Pós Graduação em Ciências Biológicas Bioquímica Toxicológica Centro de Ciências Naturais e Exatas Universidade Federal de Santa Maria Campus Universitário Camobi CEP 97105 900 Santa Maria RS Brazil

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