-
Je něco špatně v tomto záznamu ?
Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis
J. Prochazka, M. Prochazkova, W. Du, F. Spoutil, J. Tureckova, R. Hoch, T. Shimogori, R. Sedlacek, JL. Rubenstein, T. Wittmann, OD. Klein,
Developmental cell.
2015 ;
35 (6) :
713-24.
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc16020073
Online
Plný text
NLK
Cell Press Free Archives
od 2001-07-01 do Před 1 rokem
Free Medical Journals
od 2001 do Před 1 rokem
- MeSH
- epitelové buňky cytologie metabolismus MeSH
- fibroblastové růstové faktory metabolismus MeSH
- mezoderm cytologie metabolismus MeSH
- moláry cytologie embryologie metabolismus MeSH
- morfogeneze fyziologie MeSH
- myši MeSH
- odontogeneze fyziologie MeSH
- pohyb buněk fyziologie MeSH
- vývojová regulace genové exprese fyziologie MeSH
- zuby cytologie embryologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16020073
- 003
- CZ-PrNML
- 005
- 20160726102422.0
- 007
- ta
- 008
- 160722s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.devcel.2015.11.025 $2 doi
- 024 7_
- $a 10.1016/j.devcel.2015.11.025 $2 doi
- 035 __
- $a (PubMed)26702830
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Prochazka, Jan $u Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
- 245 10
- $a Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis / $c J. Prochazka, M. Prochazkova, W. Du, F. Spoutil, J. Tureckova, R. Hoch, T. Shimogori, R. Sedlacek, JL. Rubenstein, T. Wittmann, OD. Klein,
- 520 9_
- $a The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a pohyb buněk $x fyziologie $7 D002465
- 650 _2
- $a epitelové buňky $x cytologie $x metabolismus $7 D004847
- 650 _2
- $a fibroblastové růstové faktory $x metabolismus $7 D005346
- 650 _2
- $a vývojová regulace genové exprese $x fyziologie $7 D018507
- 650 _2
- $a mezoderm $x cytologie $x metabolismus $7 D008648
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a moláry $x cytologie $x embryologie $x metabolismus $7 D008963
- 650 _2
- $a morfogeneze $x fyziologie $7 D009024
- 650 _2
- $a odontogeneze $x fyziologie $7 D009805
- 650 _2
- $a zuby $x cytologie $x embryologie $7 D014070
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Prochazkova, Michaela $u Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
- 700 1_
- $a Du, Wen $u Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
- 700 1_
- $a Spoutil, Frantisek $u Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
- 700 1_
- $a Tureckova, Jolana $u Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
- 700 1_
- $a Hoch, Renee $u Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, 1500 4th Street, San Francisco, CA 94143, USA.
- 700 1_
- $a Shimogori, Tomomi $u Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, 2-1 Hirosawa Wako, Saitama 351-0198, Japan.
- 700 1_
- $a Sedlacek, Radislav $u Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the ASCR, v.v.i., Prague 4 14220, Czech Republic.
- 700 1_
- $a Rubenstein, John L $u Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, 1500 4th Street, San Francisco, CA 94143, USA.
- 700 1_
- $a Wittmann, Torsten $u Department of Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
- 700 1_
- $a Klein, Ophir D $u Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: ophir.klein@ucsf.edu.
- 773 0_
- $w MED00173658 $t Developmental cell $x 1878-1551 $g Roč. 35, č. 6 (2015), s. 713-24
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26702830 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160722 $b ABA008
- 991 __
- $a 20160726102641 $b ABA008
- 999 __
- $a ok $b bmc $g 1154743 $s 944601
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 35 $c 6 $d 713-24 $i 1878-1551 $m Developmental cell $n Dev Cell $x MED00173658
- LZP __
- $a Pubmed-20160722
