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Sampling times influence the estimate of parameters in the Weibull dissolution model
J. Cupera, P. Lansky, Z. Sklubalova,
European journal of pharmaceutical sciences.
2015 ;
78 (-) :
171-6.
[pub] 20150726
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc16020479
- MeSH
- akryláty chemie MeSH
- časové faktory MeSH
- kyselina salicylová chemie MeSH
- mannitol chemie MeSH
- rozpustnost MeSH
- teoretické modely * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The aim is to determine how well the parameters of the Weibull model of dissolution can be estimated in dependency on the chosen times to measure the empirical data. The approach is based on the theory of Fisher information. We show that in order to obtain the best estimates the data should be collected at time instants when tablets actively dissolve or at their close proximity. This is in a sharp contrast with commonly used experimental protocols when sampling times are distributed rather uniformly.
Citace poskytuje Crossref.org
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