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Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience
J. Rájová, R. Pantůček, P. Petráš, I. Varbanovová, I. Mašlaňová, J. Beneš,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT12395
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
Europe PubMed Central od 1987
ProQuest Central od 2001-02-01
Nursing & Allied Health Database (ProQuest) od 2001-02-01
Health & Medicine (ProQuest) od 2001-02-01
Public Health Database (ProQuest) od 2001-02-01
ROAD: Directory of Open Access Scholarly Resources od 1987
Odkazy
PubMed
26201459
DOI
10.1017/s0950268815001521
Knihovny.cz E-zdroje
- MeSH
- bakteriální pneumonie farmakoterapie mikrobiologie mortalita MeSH
- bakteriální toxiny biosyntéza MeSH
- dospělí MeSH
- exotoxiny biosyntéza MeSH
- genetická variace MeSH
- infekce získané v komunitě mikrobiologie MeSH
- kojenec MeSH
- leukocidiny biosyntéza MeSH
- lidé středního věku MeSH
- lidé MeSH
- methicilin rezistentní Staphylococcus aureus genetika metabolismus MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nekróza mikrobiologie MeSH
- plíce patologie MeSH
- prognóza MeSH
- prospektivní studie MeSH
- roční období MeSH
- septický šok mikrobiologie MeSH
- Staphylococcus aureus MeSH
- streptokokové infekce farmakoterapie mikrobiologie mortalita MeSH
- Check Tag
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
A prospective study (2007-2013) was undertaken to investigate clinical features and prognostic factors of necrotizing pneumonia caused by Staphylococcus aureus producing Panton-Valentine leukocidin (PVL) in the Czech Republic. Twelve cases of necrotizing pneumonia were detected in 12 patients (median age 25 years) without severe underlying disease. Eight cases occurred in December and January and the accumulation of cases in the winter months preceding the influenza season was statistically significant (P < 0·001). The course of pneumonia was very rapid, leading to early sepsis and/or septic shock in all but one patient. Seven patients died and mortality was fourfold higher in those patients presenting with primary pneumonia than with pneumonia complicating other staphylococcal/pyogenic infection elsewhere in the body. The S. aureus isolates displayed considerable genetic variability and were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30 (n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a singleton of ST154 (n = 1), all were reported to be associated with community-acquired infection. Four strains were methicillin resistant. The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed.
Department of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic
Department of Infectious Diseases 3rd Faculty of Medicine Charles University Prague Czech Republic
Reference Laboratory for Staphylococci National Institute of Public Health Prague Czech Republic
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