Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning

S. Zakharov, D. Pelclova, T. Navratil, J. Belacek, I. Kurcova, O. Komzak, T. Salek, J. Latta, R. Turek, R. Bocek, C. Kucera, JA. Hubacek, Z. Fenclova, V. Petrik, M. Cermak, KE. Hovda,

. 2014 ; 86 (1) : 199-207. [pub] 20140312

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16021100

During an outbreak of methanol poisonings in the Czech Republic in 2012, we were able to study methanol and formate elimination half-lives during intermittent hemodialysis (IHD) and continuous veno-venous hemodialysis/hemodiafiltration (CVVHD/HDF) and the relative impact of dialysate and blood flow rates on elimination. Data were obtained from 11 IHD and 13 CVVHD/HDF patients. Serum methanol and formate concentrations were measured by gas chromatography and an enzymatic method. The groups were relatively comparable, but the CVVHD/HDF group was significantly more acidotic (mean pH 6.9 vs. 7.1 IHD). The mean elimination half-life of methanol was 3.7 and formate 1.6 h with IHD, versus 8.1 and 3.6 h, respectively, with CVVHD/HDF (both significant). The 54% greater reduction in methanol and 56% reduction in formate elimination half-life during IHD resulted from the higher blood and dialysate flow rates. Increased blood and dialysate flow on the CVVHD/HDF also increased elimination significantly. Thus, IHD is superior to CVVHD/HDF for more rapid methanol and formate elimination, and if CVVHD/HDF is the only treatment available then elimination is greater with greater blood and dialysate flow rates.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16021100
003      
CZ-PrNML
005      
20250403085535.0
007      
ta
008      
160722s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/ki.2014.60 $2 doi
024    7_
$a 10.1038/ki.2014.60 $2 doi
035    __
$a (PubMed)24621917
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Zakharov, Sergey $u Department of Occupational Medicine, Toxicological Information Center, General University Hospital and First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic.
245    10
$a Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning / $c S. Zakharov, D. Pelclova, T. Navratil, J. Belacek, I. Kurcova, O. Komzak, T. Salek, J. Latta, R. Turek, R. Bocek, C. Kucera, JA. Hubacek, Z. Fenclova, V. Petrik, M. Cermak, KE. Hovda,
520    9_
$a During an outbreak of methanol poisonings in the Czech Republic in 2012, we were able to study methanol and formate elimination half-lives during intermittent hemodialysis (IHD) and continuous veno-venous hemodialysis/hemodiafiltration (CVVHD/HDF) and the relative impact of dialysate and blood flow rates on elimination. Data were obtained from 11 IHD and 13 CVVHD/HDF patients. Serum methanol and formate concentrations were measured by gas chromatography and an enzymatic method. The groups were relatively comparable, but the CVVHD/HDF group was significantly more acidotic (mean pH 6.9 vs. 7.1 IHD). The mean elimination half-life of methanol was 3.7 and formate 1.6 h with IHD, versus 8.1 and 3.6 h, respectively, with CVVHD/HDF (both significant). The 54% greater reduction in methanol and 56% reduction in formate elimination half-life during IHD resulted from the higher blood and dialysate flow rates. Increased blood and dialysate flow on the CVVHD/HDF also increased elimination significantly. Thus, IHD is superior to CVVHD/HDF for more rapid methanol and formate elimination, and if CVVHD/HDF is the only treatment available then elimination is greater with greater blood and dialysate flow rates.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a antidota $x terapeutické užití $7 D000931
650    _2
$a rychlost toku krve $7 D001783
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a formiáty $x krev $7 D005561
650    _2
$a poločas $7 D006207
650    _2
$a hemodiafiltrace $x metody $7 D017583
650    _2
$a hemodialyzační roztoky $7 D015312
650    _2
$a lidé $7 D006801
650    _2
$a koncentrace vodíkových iontů $7 D006863
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a methanol $x krev $x otrava $7 D000432
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prospektivní studie $7 D011446
650    _2
$a dialýza ledvin $x metody $7 D006435
651    _2
$a Česká republika $7 D018153
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Pelclova, Daniela $u Department of Occupational Medicine, Toxicological Information Center, General University Hospital and First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic.
700    1_
$a Navratil, Tomas $u J. Heyrovský Institute of Physical Chemistry of the AS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Belacek, Jaromir $u Institute of Biophysics and Informatics of First Faculty of Medicine of Charles University in Prague, General University Hospital, Prague, Czech Republic.
700    1_
$a Kurcova, Ivana $u Department of Toxicology, Institute of Forensic Medicine and Toxicology, General University Hospital in Prague and of the First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic.
700    1_
$a Komzak, Ondrej $u Department of Toxicology, Institute of Forensic Medicine and Toxicology, General University Hospital in Prague and of the First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic.
700    1_
$a Salek, Tomas $u Department of Clinical Biochemistry, Tomas Bata Regional Hospital in Zlin, Zlin, Czech Republic.
700    1_
$a Latta, Jiri $u Department of Internal Medicine, Tomas Bata Regional Hospital in Zlin, Zlin, Czech Republic.
700    1_
$a Turek, Radovan $u Department of Anesthesiology and Resuscitation, Tomas Bata Regional Hospital in Zlin, Zlin, Czech Republic.
700    1_
$a Bocek, Robert $u Department of Anesthesiology and Intensive Care, Hospital Havirov, Havirov, Czech Republic. $7 xx0324721
700    1_
$a Kucera, Cyril $u Department of Anesthesiology and Resuscitation, City Hospital Ostrava, Ostrava, Czech Republic.
700    1_
$a Hubacek, Jaroslav A $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Fenclová, Zdeňka, $d 1958- $u Department of Occupational Medicine, Toxicological Information Center, General University Hospital and First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic. $7 xx0074215
700    1_
$a Petrik, Vit $u Department of Occupational Medicine, Toxicological Information Center, General University Hospital and First Faculty of Medicine of Charles University in Prague, Prague, Czech Republic.
700    1_
$a Cermak, Martin $u Department of Anesthesiology and Intensive Care, Regional Hospital Pribram, Pribram, Czech Republic.
700    1_
$a Hovda, Knut Erik $u Department of Acute Medicine, The Norwegian Center for NBC Medicine, Oslo University Hospital, Ullevaal, Norway.
773    0_
$w MED00010141 $t Kidney international $x 1523-1755 $g Roč. 86, č. 1 (2014), s. 199-207
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24621917 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160722 $b ABA008
991    __
$a 20250403085531 $b ABA008
999    __
$a ok $b bmc $g 1155770 $s 945628
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 86 $c 1 $d 199-207 $e 20140312 $i 1523-1755 $m Kidney international $n Kidney Int $x MED00010141
LZP    __
$a Pubmed-20160722

Najít záznam

Citační ukazatele

Možnosti archivace