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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

S. Silva, V. Altmannova, S. Luke-Glaser, P. Henriksen, I. Gallina, X. Yang, C. Choudhary, B. Luke, L. Krejci, M. Lisby,

. 2016 ; 30 (6) : 700-17. [pub] 20160310

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16027596
E-resources Online Full text

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Links

PubMed 26966248
DOI 10.1101/gad.276204.115
Knihovny.cz E-resources

Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.

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$a Luke-Glaser, Sarah $u Institute of Molecular Biology gGmbH (IMB), 55128 Mainz, Germany;
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$a Henriksen, Peter $u The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark;
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$a Gallina, Irene $u Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark;
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$a Yang, Xuejiao $u Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark;
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$a Luke, Brian $u Institute of Molecular Biology gGmbH (IMB), 55128 Mainz, Germany;
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$a Krejci, Lumir $u Department of Biology, Masaryk University, CZ-62500 Brno, Czech Republic; National Centre for Biomolecular Research, Masaryk University, CZ-62500 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, CZ-656 91 Brno, Czech Republic; Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital Brno, CZ-656 91 Brno, Czech Republic;
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$a Lisby, Michael $u Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
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