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Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry
P. Flegontov, P. Changmai, A. Zidkova, MD. Logacheva, NE. Altınışık, O. Flegontova, MS. Gelfand, ES. Gerasimov, EE. Khrameeva, OP. Konovalova, T. Neretina, YV. Nikolsky, G. Starostin, VV. Stepanova, IV. Travinsky, M. Tříska, P. Tříska, TV. Tatarinova,
Language English Country England, Great Britain
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
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PubMed
26865217
DOI
10.1038/srep20768
Knihovny.cz E-resources
- MeSH
- Ethnicity genetics MeSH
- Phylogeny * MeSH
- Phylogeography MeSH
- Genetic Variation MeSH
- Genome, Human * MeSH
- Haplotypes MeSH
- Inuit genetics MeSH
- Language MeSH
- Polymorphism, Single Nucleotide * MeSH
- Humans MeSH
- Chromosomes, Human, Y MeSH
- Human Migration MeSH
- DNA, Mitochondrial genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Geographicals
- Siberia MeSH
The Kets, an ethnic group in the Yenisei River basin, Russia, are considered the last nomadic hunter-gatherers of Siberia, and Ket language has no transparent affiliation with any language family. We investigated connections between the Kets and Siberian and North American populations, with emphasis on the Mal'ta and Paleo-Eskimo ancient genomes, using original data from 46 unrelated samples of Kets and 42 samples of their neighboring ethnic groups (Uralic-speaking Nganasans, Enets, and Selkups). We genotyped over 130,000 autosomal SNPs, identified mitochondrial and Y-chromosomal haplogroups, and performed high-coverage genome sequencing of two Ket individuals. We established that Nganasans, Kets, Selkups, and Yukaghirs form a cluster of populations most closely related to Paleo-Eskimos in Siberia (not considering indigenous populations of Chukotka and Kamchatka). Kets are closely related to modern Selkups and to some Bronze and Iron Age populations of the Altai region, with all these groups sharing a high degree of Mal'ta ancestry. Implications of these findings for the linguistic hypothesis uniting Ket and Na-Dene languages into a language macrofamily are discussed.
Belozersky Institute of Physico Chemical Biology Lomonosov Moscow State University Moscow Russia
Biomedical Cluster Skolkovo Foundation Skolkovo Russia George Mason University Fairfax VA USA
Children's Hospital Los Angeles Los Angeles CA USA
Department of Biology and Ecology Faculty of Science University of Ostrava Ostrava Czech Republic
Institute of Parasitology Biology Centre Czech Academy of Sciences České Budĕjovice Czech Republic
Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto Portugal
Russian State University for the Humanities Moscow Russia Russian Presidential Academy Moscow Russia
References provided by Crossref.org
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