-
Je něco špatně v tomto záznamu ?
Associations of polymorphisms in bovine DGAT1, FABP4, FASN, and PPARGC1A genes with intramuscular fat content and the fatty acid composition of muscle and subcutaneous fat in Fleckvieh bulls
L. Bartoň, D. Bureš, T. Kott, D. Řehák,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- alely MeSH
- ateroskleróza MeSH
- diacylglycerol-O-acyltransferasa genetika metabolismus MeSH
- druhová specificita MeSH
- fenotyp * MeSH
- genotyp * MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- maso analýza MeSH
- mastné kyseliny metabolismus MeSH
- podkožní tuk metabolismus MeSH
- polymorfismus genetický * MeSH
- proteiny vázající mastné kyseliny genetika metabolismus MeSH
- skot MeSH
- svaly metabolismus MeSH
- syntázy mastných kyselin genetika metabolismus MeSH
- transkripční faktory genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Allelic and genotypic distribution of polymorphisms in diacylglycerol acyltransferase 1 (DGAT1), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN), and peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) genes were assessed in 679 Fleckvieh bulls. Single-locus genotype effects and the combined effect of the two polymorphisms within the FASN gene were evaluated for association with the intramuscular fat content and fatty acid profile determined in muscle and subcutaneous fat. The FASN (g.16024G>A) and FASN (g.17924A>G) polymorphisms were significantly associated mainly with C14:0, C16:0, and C18:1 n-9 concentrations as well as with the atherogenic index. The proportion of explained phenotypic variation markedly increased when the effect of a combination of the two polymorphisms within the FASN gene was tested, with the highest values of 8.6% and 14.8%, respectively, observed for C14:0 in muscle and subcutaneous fat. With a focus on improving the fatty acid composition of beef, the results of this study provide valuable information about the markers applicable in marker-assisted selection.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17000707
- 003
- CZ-PrNML
- 005
- 20170120104547.0
- 007
- ta
- 008
- 170103s2016 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.meatsci.2015.12.004 $2 doi
- 024 7_
- $a 10.1016/j.meatsci.2015.12.004 $2 doi
- 035 __
- $a (PubMed)26720887
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Bartoň, L $u Institute of Animal Science, Prague 10 CZ 104 01, Czech Republic. Electronic address: barton.ludek@vuzv.cz.
- 245 10
- $a Associations of polymorphisms in bovine DGAT1, FABP4, FASN, and PPARGC1A genes with intramuscular fat content and the fatty acid composition of muscle and subcutaneous fat in Fleckvieh bulls / $c L. Bartoň, D. Bureš, T. Kott, D. Řehák,
- 520 9_
- $a Allelic and genotypic distribution of polymorphisms in diacylglycerol acyltransferase 1 (DGAT1), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN), and peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) genes were assessed in 679 Fleckvieh bulls. Single-locus genotype effects and the combined effect of the two polymorphisms within the FASN gene were evaluated for association with the intramuscular fat content and fatty acid profile determined in muscle and subcutaneous fat. The FASN (g.16024G>A) and FASN (g.17924A>G) polymorphisms were significantly associated mainly with C14:0, C16:0, and C18:1 n-9 concentrations as well as with the atherogenic index. The proportion of explained phenotypic variation markedly increased when the effect of a combination of the two polymorphisms within the FASN gene was tested, with the highest values of 8.6% and 14.8%, respectively, observed for C14:0 in muscle and subcutaneous fat. With a focus on improving the fatty acid composition of beef, the results of this study provide valuable information about the markers applicable in marker-assisted selection.
- 650 _2
- $a alely $7 D000483
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a ateroskleróza $7 D050197
- 650 _2
- $a skot $7 D002417
- 650 _2
- $a diacylglycerol-O-acyltransferasa $x genetika $x metabolismus $7 D051048
- 650 _2
- $a syntázy mastných kyselin $x genetika $x metabolismus $7 D064429
- 650 _2
- $a proteiny vázající mastné kyseliny $x genetika $x metabolismus $7 D050556
- 650 _2
- $a mastné kyseliny $x metabolismus $7 D005227
- 650 12
- $a genotyp $7 D005838
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a maso $x analýza $7 D008460
- 650 _2
- $a svaly $x metabolismus $7 D009132
- 650 12
- $a fenotyp $7 D010641
- 650 12
- $a polymorfismus genetický $7 D011110
- 650 _2
- $a jednonukleotidový polymorfismus $7 D020641
- 650 _2
- $a druhová specificita $7 D013045
- 650 _2
- $a podkožní tuk $x metabolismus $7 D050151
- 650 _2
- $a transkripční faktory $x genetika $x metabolismus $7 D014157
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Bureš, D $u Institute of Animal Science, Prague 10 CZ 104 01, Czech Republic.
- 700 1_
- $a Kott, T $u Institute of Animal Science, Prague 10 CZ 104 01, Czech Republic.
- 700 1_
- $a Řehák, D $u Institute of Animal Science, Prague 10 CZ 104 01, Czech Republic.
- 773 0_
- $w MED00006478 $t Meat science $x 1873-4138 $g Roč. 114, č. - (2016), s. 18-23
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26720887 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170103 $b ABA008
- 991 __
- $a 20170120104657 $b ABA008
- 999 __
- $a ok $b bmc $g 1179847 $s 961274
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 114 $c - $d 18-23 $e 20151217 $i 1873-4138 $m Meat science $n Meat Sci $x MED00006478
- LZP __
- $a Pubmed-20170103
