Associations of polymorphisms in bovine DGAT1, FABP4, FASN, and PPARGC1A genes with intramuscular fat content and the fatty acid composition of muscle and subcutaneous fat in Fleckvieh bulls
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26720887
DOI
10.1016/j.meatsci.2015.12.004
PII: S0309-1740(15)30142-X
Knihovny.cz E-zdroje
- Klíčová slova
- Adipose tissue, Cattle, Fatty acid, Gene polymorphism,
- MeSH
- alely MeSH
- ateroskleróza MeSH
- diacylglycerol-O-acyltransferasa genetika metabolismus MeSH
- druhová specificita MeSH
- fenotyp * MeSH
- genotyp * MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- maso analýza MeSH
- mastné kyseliny metabolismus MeSH
- podkožní tuk metabolismus MeSH
- polymorfismus genetický * MeSH
- proteiny vázající mastné kyseliny genetika metabolismus MeSH
- skot MeSH
- svaly metabolismus MeSH
- syntázy mastných kyselin genetika metabolismus MeSH
- transkripční faktory genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- diacylglycerol-O-acyltransferasa MeSH
- mastné kyseliny MeSH
- proteiny vázající mastné kyseliny MeSH
- syntázy mastných kyselin MeSH
- transkripční faktory MeSH
Allelic and genotypic distribution of polymorphisms in diacylglycerol acyltransferase 1 (DGAT1), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN), and peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) genes were assessed in 679 Fleckvieh bulls. Single-locus genotype effects and the combined effect of the two polymorphisms within the FASN gene were evaluated for association with the intramuscular fat content and fatty acid profile determined in muscle and subcutaneous fat. The FASN (g.16024G>A) and FASN (g.17924A>G) polymorphisms were significantly associated mainly with C14:0, C16:0, and C18:1 n-9 concentrations as well as with the atherogenic index. The proportion of explained phenotypic variation markedly increased when the effect of a combination of the two polymorphisms within the FASN gene was tested, with the highest values of 8.6% and 14.8%, respectively, observed for C14:0 in muscle and subcutaneous fat. With a focus on improving the fatty acid composition of beef, the results of this study provide valuable information about the markers applicable in marker-assisted selection.
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