BACKGROUND: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion. METHODS: The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient. RESULTS: Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025). CONCLUSION: GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure.

1st Department of Internal Medicine Cardioangiology University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove Charles University Prague

2nd Department of Internal Medicine Gastroenterology University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove Charles University Prague

Department of Oncology 1st Faculty of Medicine Charles University Prague and Thomayer University Hospital Prague

Institute of Clinical Biochemistry and Diagnostics University Hospital in Hradec Kralove Czech Republic