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The miR-29 family in hematological malignancies

B. Fiserova, L. Kubiczkova, L. Sedlarikova, R. Hajek, S. Sevcikova

. 2015 ; 159 (2) : 184-191. [pub] 20140704

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc17006074

Grant support
NT12130 MZ0 CEP Register
NT14575 MZ0 CEP Register

BACKGROUND: MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies. CONCLUSION: Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.

References provided by Crossref.org

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