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Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

V. Švachová, L. Vojtová, D. Pavliňák, L. Vojtek, V. Sedláková, P. Hyršl, M. Alberti, J. Jaroš, A. Hampl, J. Jančář,

. 2016 ; 67 (-) : 493-501. [pub] 20160516

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023919

Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.

Citace poskytuje Crossref.org

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$a Vojtová, Lucy $u CEITEC - Central European Institute of Technology, Brno University of Technology, Czech Republic; SCITEG, a.s., Brno, Czech Republic.
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$a Pavliňák, David $u Department of Physical Electronics, Masaryk University, Czech Republic.
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$a Vojtek, Libor $u Institute of Experimental Biology, Masaryk University, Czech Republic.
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$a Sedláková, Veronika $u Department of Histology and Embryology, Masaryk University, Czech Republic; International Clinical Research, St. Anne's University Hospital, Brno, Czech Republic.
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$a Hyršl, Pavel $u Institute of Experimental Biology, Masaryk University, Czech Republic.
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$a Jaroš, Josef $u Department of Histology and Embryology, Masaryk University, Czech Republic; International Clinical Research, St. Anne's University Hospital, Brno, Czech Republic.
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$a Hampl, Aleš $u Department of Histology and Embryology, Masaryk University, Czech Republic; International Clinical Research, St. Anne's University Hospital, Brno, Czech Republic.
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$a Jančář, Josef $u Institute of Materials Chemistry, Brno University of Technology, Czech Republic; CEITEC - Central European Institute of Technology, Brno University of Technology, Czech Republic; SCITEG, a.s., Brno, Czech Republic.
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