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FGF signaling refines Wnt gradients to regulate the patterning of taste papillae
M. Prochazkova, TJ. Häkkinen, J. Prochazka, F. Spoutil, AH. Jheon, Y. Ahn, R. Krumlauf, J. Jernvall, OD. Klein,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1953 do Před 6 měsíci
Open Access Digital Library
od 1953-03-01 do Před 6 měsíci
PubMed
28506989
DOI
10.1242/dev.148080
Knihovny.cz E-zdroje
- MeSH
- biologické modely MeSH
- chuťové pohárky embryologie metabolismus MeSH
- fibroblastový růstový faktor 10 nedostatek genetika metabolismus MeSH
- intracelulární signální peptidy a proteiny nedostatek genetika metabolismus MeSH
- kostní morfogenetické proteiny genetika metabolismus MeSH
- membránové proteiny nedostatek genetika metabolismus MeSH
- myši knockoutované MeSH
- myši transgenní MeSH
- myši MeSH
- počítačová simulace MeSH
- proteiny hedgehog genetika metabolismus MeSH
- rozvržení tělního plánu genetika fyziologie MeSH
- signální dráha Wnt * MeSH
- těhotenství MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue. Here, we report that FGF signaling is a crucial regulator of fungiform papillae development. We found that mesenchymal FGF10 controls the size of the papillary area, while overall patterning remains unchanged. Our results show that FGF signaling negatively affects the extent of canonical Wnt signaling, which is the main activation pathway during fungiform papillae development; however, this effect does not occur at the level of gene transcription. Rather, our experimental data, together with computational modeling, indicate that FGF10 modulates the range of Wnt effects, likely via induction of Sostdc1 expression. We suggest that modification of the reach of Wnt signaling could be due to local changes in morphogen diffusion, representing a novel mechanism in this tissue context, and we propose that this phenomenon might be involved in a broader array of mammalian developmental processes.
Citace poskytuje Crossref.org
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- $a The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue. Here, we report that FGF signaling is a crucial regulator of fungiform papillae development. We found that mesenchymal FGF10 controls the size of the papillary area, while overall patterning remains unchanged. Our results show that FGF signaling negatively affects the extent of canonical Wnt signaling, which is the main activation pathway during fungiform papillae development; however, this effect does not occur at the level of gene transcription. Rather, our experimental data, together with computational modeling, indicate that FGF10 modulates the range of Wnt effects, likely via induction of Sostdc1 expression. We suggest that modification of the reach of Wnt signaling could be due to local changes in morphogen diffusion, representing a novel mechanism in this tissue context, and we propose that this phenomenon might be involved in a broader array of mammalian developmental processes.
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