• Je něco špatně v tomto záznamu ?

Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome

E. Azoulay, P. Knoebl, J. Garnacho-Montero, K. Rusinova, G. Galstian, P. Eggimann, F. Abroug, D. Benoit, M. von Bergwelt-Baildon, J. Wendon, M. Scully,

. 2017 ; 152 (2) : 424-434. [pub] 20170423

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc17030860

A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis. Similarity in clinical presentation may hinder diagnosis and optimal treatment selection in the urgent setting in the ICU. However, there is currently no consensus on the diagnosis or treatment of aHUS for ICU specialists. This review aims to summarize available data on the diagnosis and treatment strategies of aHUS in the ICU to enhance the understanding of aHUS diagnosis and outcomes in patients managed in the ICU. To this end, a review of the recent literature (January 2009-March 2016) was performed to select the most relevant articles for ICU physicians. Based on the paucity of adult aHUS cases overall and within the ICU, no specific recommendations could be formally graded for the critical care setting. However, we recognize a core set of skills required by intensivists for diagnosing and managing patients with aHUS: recognizing thrombotic microangiopathies, differentiating aHUS from related conditions, recognizing involvement of other organ systems, understanding the pathophysiology of aHUS, knowing the diagnostic workup and relevant outcomes in critically ill patients with aHUS, and knowing the standard of care for patients with aHUS based on available data and guidelines. In conclusion, managing critically ill patients with aHUS requires basic skills that, in the absence of sufficient data from patients treated within the ICU, can be gleaned from an increasingly relevant literature outside the ICU. More data on critically ill patients with aHUS are needed to validate these conclusions within the ICU setting.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17030860
003      
CZ-PrNML
005      
20171102122357.0
007      
ta
008      
171025s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.chest.2017.03.055 $2 doi
035    __
$a (PubMed)28442312
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Azoulay, Elie $u Medical Intensive Care Unit, Hôpital Saint-Louis, Paris, France. Electronic address: elie.azoulay@sls.aphp.fr. $7 gn_A_00010759
245    10
$a Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome / $c E. Azoulay, P. Knoebl, J. Garnacho-Montero, K. Rusinova, G. Galstian, P. Eggimann, F. Abroug, D. Benoit, M. von Bergwelt-Baildon, J. Wendon, M. Scully,
520    9_
$a A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis. Similarity in clinical presentation may hinder diagnosis and optimal treatment selection in the urgent setting in the ICU. However, there is currently no consensus on the diagnosis or treatment of aHUS for ICU specialists. This review aims to summarize available data on the diagnosis and treatment strategies of aHUS in the ICU to enhance the understanding of aHUS diagnosis and outcomes in patients managed in the ICU. To this end, a review of the recent literature (January 2009-March 2016) was performed to select the most relevant articles for ICU physicians. Based on the paucity of adult aHUS cases overall and within the ICU, no specific recommendations could be formally graded for the critical care setting. However, we recognize a core set of skills required by intensivists for diagnosing and managing patients with aHUS: recognizing thrombotic microangiopathies, differentiating aHUS from related conditions, recognizing involvement of other organ systems, understanding the pathophysiology of aHUS, knowing the diagnostic workup and relevant outcomes in critically ill patients with aHUS, and knowing the standard of care for patients with aHUS based on available data and guidelines. In conclusion, managing critically ill patients with aHUS requires basic skills that, in the absence of sufficient data from patients treated within the ICU, can be gleaned from an increasingly relevant literature outside the ICU. More data on critically ill patients with aHUS are needed to validate these conclusions within the ICU setting.
650    _2
$a protein ADAMTS13 $x metabolismus $7 D000071120
650    _2
$a dospělí $7 D000328
650    _2
$a atypický hemolyticko-uremický syndrom $x diagnóza $x etiologie $x terapie $7 D065766
650    _2
$a komplement $x metabolismus $7 D003165
650    _2
$a péče o pacienty v kritickém stavu $x normy $7 D003422
650    _2
$a diferenciální diagnóza $7 D003937
650    _2
$a genetické testování $x metody $7 D005820
650    _2
$a lidé $7 D006801
650    _2
$a výměna plazmy $x metody $7 D010951
650    _2
$a kvalita zdravotní péče $x normy $7 D011787
650    _2
$a standardní péče $7 D059039
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Knoebl, Paul $u Medical University of Vienna, Vienna General Hospital, Vienna, Austria.
700    1_
$a Garnacho-Montero, José $u Virgen de Macarena University Hospital, Seville, Spain.
700    1_
$a Rusinova, Katerina $u University Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Galstian, Gennadii $u National Research Center for Hematology, Russia.
700    1_
$a Eggimann, Philippe $u University Hospital of Lausanne, Lausanne, Switzerland.
700    1_
$a Abroug, Fekri $u Fattouma Bourguiba Teaching Hospital Monastir, Tunisia. $7 gn_A_00000847
700    1_
$a Benoit, Dominique $u Ghent University Hospital, Ghent, Belgium.
700    1_
$a von Bergwelt-Baildon, Michael $u Uniklinik, Cologne, Germany.
700    1_
$a Wendon, Julia $u King's College Hospital, London, England.
700    1_
$a Scully, Marie $u University College London, London, England.
773    0_
$w MED00002127 $t Chest $x 1931-3543 $g Roč. 152, č. 2 (2017), s. 424-434
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28442312 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171102122450 $b ABA008
999    __
$a ok $b bmc $g 1254453 $s 991887
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 152 $c 2 $d 424-434 $e 20170423 $i 1931-3543 $m Chest $n Chest $x MED00002127
LZP    __
$a Pubmed-20171025

Najít záznam

Citační ukazatele

Možnosti archivace