-
Je něco špatně v tomto záznamu ?
Low predictive value of histopathological scoring system for complications development in children with Crohn's disease
O. Fabian, O. Hradsky, K. Potuznikova, A. Kalfusova, L. Krskova, L. Hornofova, J. Zamecnik, J. Bronsky,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
- MeSH
- Crohnova nemoc komplikace patologie MeSH
- dítě MeSH
- gastrointestinální endoskopie MeSH
- lidé MeSH
- mladiství MeSH
- prediktivní hodnota testů MeSH
- retrospektivní studie MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: In pediatric Crohn's disease (PCD), the benefit of microscopy in disease activity assessment and prediction of clinical outcome is, due to the focality and transmurality of the inflammation, disputable. We investigated whether histopathological scoring system predicts complications in pediatric CD and correlates with endoscopical and clinical scores. METHODS: We performed a retrospective study on 63 patients. Endoscopy in the time of diagnosis was evaluated using the Simple Endoscopic Score (SES) and histopathology with the Global Histology Activity Score, both in its original version (GHAS) and its modification (modGHAS). Pediatric Crohn's Disease Activity Index (PCDAI) was also calculated. The patients were grouped according to the presence or absence of defined complications (intraabdominal abscess or fistula, perianal fistulating disease or stricture impenetrable for endoscope or with prestenotic dilatation) during one year of follow-up, or the necessity to initiate anti-TNF treatment for persisting or relapsing active disease in the same time period. Associations were tested with Cox regression analysis. RESULTS: SES was higher in patients with complications. However, in case of GHAS, modGHAS and PCDAI we did not find any significant association with complicated course of disease. SES above 16 points was revealed as an independent risk factor for complications development in PCD, in contrary to GHAS, modGHAS and PCDAI. We demonstrated only a weak correlation between GHAS, modGHAS and SES and no correlation between the histopathological scoring systems and PCDAI. CONCLUSIONS: In conclusion, the histopathological scoring system cannot be recommended as a reliable predictor of development of complications in children with CD.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17031029
- 003
- CZ-PrNML
- 005
- 20221021084527.0
- 007
- ta
- 008
- 171025s2017 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.prp.2017.01.009 $2 doi
- 035 __
- $a (PubMed)28216137
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Fabián, Ondřej $7 xx0228104 $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia. Electronic address: Ondrej.Fabian2@fnmotol.cz.
- 245 10
- $a Low predictive value of histopathological scoring system for complications development in children with Crohn's disease / $c O. Fabian, O. Hradsky, K. Potuznikova, A. Kalfusova, L. Krskova, L. Hornofova, J. Zamecnik, J. Bronsky,
- 520 9_
- $a OBJECTIVES: In pediatric Crohn's disease (PCD), the benefit of microscopy in disease activity assessment and prediction of clinical outcome is, due to the focality and transmurality of the inflammation, disputable. We investigated whether histopathological scoring system predicts complications in pediatric CD and correlates with endoscopical and clinical scores. METHODS: We performed a retrospective study on 63 patients. Endoscopy in the time of diagnosis was evaluated using the Simple Endoscopic Score (SES) and histopathology with the Global Histology Activity Score, both in its original version (GHAS) and its modification (modGHAS). Pediatric Crohn's Disease Activity Index (PCDAI) was also calculated. The patients were grouped according to the presence or absence of defined complications (intraabdominal abscess or fistula, perianal fistulating disease or stricture impenetrable for endoscope or with prestenotic dilatation) during one year of follow-up, or the necessity to initiate anti-TNF treatment for persisting or relapsing active disease in the same time period. Associations were tested with Cox regression analysis. RESULTS: SES was higher in patients with complications. However, in case of GHAS, modGHAS and PCDAI we did not find any significant association with complicated course of disease. SES above 16 points was revealed as an independent risk factor for complications development in PCD, in contrary to GHAS, modGHAS and PCDAI. We demonstrated only a weak correlation between GHAS, modGHAS and SES and no correlation between the histopathological scoring systems and PCDAI. CONCLUSIONS: In conclusion, the histopathological scoring system cannot be recommended as a reliable predictor of development of complications in children with CD.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a Crohnova nemoc $x komplikace $x patologie $7 D003424
- 650 _2
- $a gastrointestinální endoskopie $7 D016099
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a stupeň závažnosti nemoci $7 D012720
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Hradsky, Ondrej $u Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 700 1_
- $a Potuznikova, Kristyna $u Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 700 1_
- $a Kalfusová, Alena $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia. $7 xx0277867
- 700 1_
- $a Krskova, Lenka $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 700 1_
- $a Hornofova, Ludmila $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 700 1_
- $a Zamecnik, Josef $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 700 1_
- $a Bronsky, Jiri $u Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague 5, 150 06, Czechia.
- 773 0_
- $w MED00003712 $t Pathology, research and practice $x 1618-0631 $g Roč. 213, č. 4 (2017), s. 353-358
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28216137 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20171025 $b ABA008
- 991 __
- $a 20221021084520 $b ABA008
- 999 __
- $a ok $b bmc $g 1254622 $s 992056
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 213 $c 4 $d 353-358 $e 20170115 $i 1618-0631 $m Pathology, research and practice $n Pathol Res Pract $x MED00003712
- LZP __
- $a Pubmed-20171025
