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GABA spectra and remote distractor effect in progressive supranuclear palsy: A pilot study
C. Bonnet, J. Rusz, J. Hanuška, M. Dezortová, F. Jírů, T. Sieger, R. Jech, J. Klempíř, J. Roth, O. Bezdíček, T. Serranová, P. Dušek, T. Uher, C. Flammand-Roze, M. Hájek, E. Růžička,
Revue neurologique.
2017 ;
173 (4) :
225-229.
[pub] 20170403
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc18010695
Grantová podpora
NT12288
MZ0
CEP - Centrální evidence projektů
- MeSH
- GABA metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- magnetická rezonanční tomografie MeSH
- okulomotorické svaly diagnostické zobrazování patofyziologie MeSH
- pilotní projekty MeSH
- pohyby očí MeSH
- prefrontální mozková kůra diagnostické zobrazování metabolismus MeSH
- progresivní supranukleární obrna diagnostické zobrazování metabolismus psychologie MeSH
- sakadické oční pohyby MeSH
- senioři MeSH
- světelná stimulace MeSH
- zdraví dobrovolníci pro lékařské studie MeSH
- zraková pole MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Disturbances of the gamma-aminobutyric-acid (GABA) system have been suspected of contributing to the pathophysiology of progressive supranuclear palsy (PSP). The ability to rapidly resolve competitive action decisions, such as shifting the gaze to one particular stimulus rather than another, can be predicted by the concentration of GABA in the region of the frontal cortex relevant to eye movements. For this reason, our study measured GABA levels in seven PSP patients and eight healthy controls, using proton magnetic resonance spectroscopy, and assessed the relationship of these measurements to the remote distractor effect (RDE), an eye-movement paradigm investigating competitive action decisions. No significant differences were found in either frontal-eye-field GABA levels or RDE between PSP patients and controls.
AP HP Hospital de Bicêtre Department of Neurology 94270 Paris France
Department of Neurology Pitié Salpêtrière Hospital AP HP 75013 Paris France
Department of Neurosurgery Hospital Na Homolce Prague Czech Republic
Citace poskytuje Crossref.org
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- $a Disturbances of the gamma-aminobutyric-acid (GABA) system have been suspected of contributing to the pathophysiology of progressive supranuclear palsy (PSP). The ability to rapidly resolve competitive action decisions, such as shifting the gaze to one particular stimulus rather than another, can be predicted by the concentration of GABA in the region of the frontal cortex relevant to eye movements. For this reason, our study measured GABA levels in seven PSP patients and eight healthy controls, using proton magnetic resonance spectroscopy, and assessed the relationship of these measurements to the remote distractor effect (RDE), an eye-movement paradigm investigating competitive action decisions. No significant differences were found in either frontal-eye-field GABA levels or RDE between PSP patients and controls.
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