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Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma

L. Boldrup, X. Gu, PJ. Coates, L. Norberg-Spaak, R. Fahraeus, G. Laurell, T. Wilms, K. Nylander,

. 2017 ; 8 (12) : 19389-19402.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016832

Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.

Citace poskytuje Crossref.org

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$a Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.
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$a Gu, Xiaolian $u Department of Medical Biosciences/Pathology, Umeå University, SE - 901 85 Umeå, Sweden.
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$a Coates, Philip J $u RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
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$a Norberg-Spaak, Lena $u Department of Clinical Sciences/ENT Umeå University, SE - 901 85 Umeå, Sweden.
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