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Nano-selenium and its nanomedicine applications: a critical review

B. Hosnedlova, M. Kepinska, S. Skalickova, C. Fernandez, B. Ruttkay-Nedecky, Q. Peng, M. Baron, M. Melcova, R. Opatrilova, J. Zidkova, G. Bjørklund, J. Sochor, R. Kizek,

. 2018 ; 13 (-) : 2107-2128. [pub] 20180410

Language English Country New Zealand

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc18024235

Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration.

References provided by Crossref.org

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$a Hosnedlová, Božena $7 xx0240321 $u Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Lednice, Czech Republic.
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$a Nano-selenium and its nanomedicine applications: a critical review / $c B. Hosnedlova, M. Kepinska, S. Skalickova, C. Fernandez, B. Ruttkay-Nedecky, Q. Peng, M. Baron, M. Melcova, R. Opatrilova, J. Zidkova, G. Bjørklund, J. Sochor, R. Kizek,
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$a Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration.
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$a Kepinska, Marta $u Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
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$a Skalickova, Sylvie $u Central Laboratory, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
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$a Fernandez, Carlos $u School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK.
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$a Ruttkay-Nedecký, Branislav $7 xx0237909 $u Central Laboratory, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
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$a Peng, Qiuming $u State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, People's Republic of China.
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$a Baron, Mojmir $u Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Lednice, Czech Republic.
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$a Melcova, Magdalena $u Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic.
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$a Opatrilova, Radka $u Central Laboratory, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
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$a Zidkova, Jarmila $u Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic.
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$a Sochor, Jiri $u Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Lednice, Czech Republic.
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$a Kizek, Rene $u Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland. Central Laboratory, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
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