• Je něco špatně v tomto záznamu ?

M1/M2 macrophage polarization in human obese adipose tissue

J. Chylikova, J. Dvorackova, Z. Tauber, V. Kamarad

. 2018 ; 162 (2) : 79-82. [pub] 20180516

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc18038657

Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18038657
003      
CZ-PrNML
005      
20181203081703.0
007      
ta
008      
181123s2018 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2018.015 $2 doi
035    __
$a (PubMed)29765169
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Chylikova, Jaroslava $u Department of Histology and Embryology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
245    10
$a M1/M2 macrophage polarization in human obese adipose tissue / $c J. Chylikova, J. Dvorackova, Z. Tauber, V. Kamarad
520    9_
$a Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.
650    _2
$a tuková tkáň $x patologie $7 D000273
650    _2
$a chemokin CCL2 $x metabolismus $7 D018932
650    _2
$a lidé $7 D006801
650    _2
$a hypoxie $x metabolismus $x patologie $7 D000860
650    _2
$a inzulinová rezistence $x fyziologie $7 D007333
650    _2
$a interleukin-6 $x metabolismus $7 D015850
650    _2
$a makrofágy $x patologie $7 D008264
650    _2
$a obezita $x metabolismus $x patologie $7 D009765
650    _2
$a fenotyp $7 D010641
650    _2
$a TNF-alfa $x metabolismus $7 D014409
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Dvořáčková, Jana, $u Department of Pathology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic. $d 1956- $7 xx0077620
700    1_
$a Tauber, Zdeněk $u Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. $7 xx0228394
700    1_
$a Kamarád, Vojtěch $u Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. $7 jx20110416001
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 162, č. 2 (2018), s. 79-82
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29765169 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20181123 $b ABA008
991    __
$a 20181128132358 $b ABA008
999    __
$a ok $b bmc $g 1356006 $s 1035696
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 162 $c 2 $d 79-82 $e 20180516 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20181123

Najít záznam

Citační ukazatele

Možnosti archivace