M1/M2 macrophage polarization in human obese adipose tissue
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
29765169
DOI
10.5507/bp.2018.015
Knihovny.cz E-resources
- Keywords
- M1/M2 macrophages, adipose tissue, chemokines, inflammation, obesity,
- MeSH
- Chemokine CCL2 metabolism MeSH
- Phenotype MeSH
- Hypoxia metabolism pathology MeSH
- Interleukin-6 metabolism MeSH
- Insulin Resistance physiology MeSH
- Humans MeSH
- Macrophages pathology MeSH
- Obesity metabolism pathology MeSH
- Tumor Necrosis Factor-alpha metabolism MeSH
- Adipose Tissue pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- CCL2 protein, human MeSH Browser
- Chemokine CCL2 MeSH
- Interleukin-6 MeSH
- Tumor Necrosis Factor-alpha MeSH
Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.
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