-
Something wrong with this record ?
Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study
L. Brunerová, R. Lažanská, P. Kasalický, J. Verešová, J. Potočková, A. Fialová, I. Rychlík,
Language English Country Netherlands
Document type Journal Article
NLK
ProQuest Central
from 1999-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-03-01 to 1 year ago
Health & Medicine (ProQuest)
from 1999-01-01 to 1 year ago
- MeSH
- Acyltransferases blood MeSH
- Kidney Failure, Chronic blood therapy MeSH
- Fractures, Bone blood epidemiology MeSH
- Hemodiafiltration MeSH
- Body Mass Index * MeSH
- Bone Density MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Parathyroid Hormone blood MeSH
- Escherichia coli Proteins blood MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Vitamin D analogs & derivatives blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
PURPOSE: Bone involvement represents one of the complications of end-stage chronic kidney disease, with fractures being its major risk. The aim of our study was to assess the frequency and predictors of low-trauma fractures in a cohort of maintenance hemodialysis patients followed-up on for 2 years. METHODS: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafiltration underwent initially laboratory (markers of calcium-phosphate metabolism and bone turnover markers) and densitometry examination with TBS assessment (Lunar Prodigy, TBS software 2.1.2). During 24-month follow-up, the frequency of low-trauma fractures was assessed and possible predictors of increased fracture risk were identified using product-moment correlation matrices. RESULTS: Altogether 7 (11.9%) low-trauma fractures were observed. In the whole group, age (P = 0.047), T-score in proximal femur (P = 0.04), low vitamin D, low BMI (P = 0.03 for both), and higher FRAX for major osteoporotic fracture (P = 0.01) were connected with fractures, but in multi-variate analysis only BMI remained significantly negatively associated with fractures (P = 0.047). TBS and bone turnover markers failed to predict fractures. However, women with fractures had significantly lower serum phosphate (P = 0.03) and higher parathyroid hormone (P = 0.04). Parameters of hip structure analysis significantly correlated with FRAX, but not with fractures. CONCLUSIONS: In a group of hemodialysis patients from one centre, T-score in proximal femur, low vitamin D, low BMI, and high FRAX for major osteoporotic fracture were associated with low-trauma fractures, however, in multi-variate analysis only low BMI remained a significant predictor of fracture risk.
Bone Metabolism Unit Affidea Prague Czech Republic
Dialysis Centre Fresenius Medical Care Vinohrady Prague Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19000447
- 003
- CZ-PrNML
- 005
- 20190121103310.0
- 007
- ta
- 008
- 190107s2018 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s11255-018-1958-y $2 doi
- 035 __
- $a (PubMed)30117013
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Brunerová, Ludmila $u II. Internal Department, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic. brunerova@seznam.cz. Bone Metabolism Unit, Affidea, Prague, Czech Republic. brunerova@seznam.cz.
- 245 10
- $a Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study / $c L. Brunerová, R. Lažanská, P. Kasalický, J. Verešová, J. Potočková, A. Fialová, I. Rychlík,
- 520 9_
- $a PURPOSE: Bone involvement represents one of the complications of end-stage chronic kidney disease, with fractures being its major risk. The aim of our study was to assess the frequency and predictors of low-trauma fractures in a cohort of maintenance hemodialysis patients followed-up on for 2 years. METHODS: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafiltration underwent initially laboratory (markers of calcium-phosphate metabolism and bone turnover markers) and densitometry examination with TBS assessment (Lunar Prodigy, TBS software 2.1.2). During 24-month follow-up, the frequency of low-trauma fractures was assessed and possible predictors of increased fracture risk were identified using product-moment correlation matrices. RESULTS: Altogether 7 (11.9%) low-trauma fractures were observed. In the whole group, age (P = 0.047), T-score in proximal femur (P = 0.04), low vitamin D, low BMI (P = 0.03 for both), and higher FRAX for major osteoporotic fracture (P = 0.01) were connected with fractures, but in multi-variate analysis only BMI remained significantly negatively associated with fractures (P = 0.047). TBS and bone turnover markers failed to predict fractures. However, women with fractures had significantly lower serum phosphate (P = 0.03) and higher parathyroid hormone (P = 0.04). Parameters of hip structure analysis significantly correlated with FRAX, but not with fractures. CONCLUSIONS: In a group of hemodialysis patients from one centre, T-score in proximal femur, low vitamin D, low BMI, and high FRAX for major osteoporotic fracture were associated with low-trauma fractures, however, in multi-variate analysis only low BMI remained a significant predictor of fracture risk.
- 650 _2
- $a acyltransferasy $x krev $7 D000217
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 12
- $a index tělesné hmotnosti $7 D015992
- 650 _2
- $a kostní denzita $7 D015519
- 650 _2
- $a proteiny z Escherichia coli $x krev $7 D029968
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a fraktury kostí $x krev $x epidemiologie $7 D050723
- 650 _2
- $a hemodiafiltrace $7 D017583
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a chronické selhání ledvin $x krev $x terapie $7 D007676
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a parathormon $x krev $7 D010281
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a vitamin D $x analogy a deriváty $x krev $7 D014807
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Lažanská, Renata $u Dialysis Centre, Fresenius Medical Care, Vinohrady, Prague, Czech Republic.
- 700 1_
- $a Kasalický, Petr $u Bone Metabolism Unit, Affidea, Prague, Czech Republic.
- 700 1_
- $a Verešová, Jana $u Dialysis Centre, Fresenius Medical Care, Vinohrady, Prague, Czech Republic.
- 700 1_
- $a Potočková, Jana $u II. Internal Department, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.
- 700 1_
- $a Fialová, Alena $u National Institute of Public Health, Prague, Czech Republic.
- 700 1_
- $a Rychlík, Ivan $u I. Internal Department, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 773 0_
- $w MED00002396 $t International urology and nephrology $x 1573-2584 $g Roč. 50, č. 9 (2018), s. 1721-1728
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30117013 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20190121103529 $b ABA008
- 999 __
- $a ok $b bmc $g 1364530 $s 1038570
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 50 $c 9 $d 1721-1728 $e 20180816 $i 1573-2584 $m International urology and nephrology $n Int Urol Nephrol $x MED00002396
- LZP __
- $a Pubmed-20190107
