• Something wrong with this record ?

Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press

W. Grymonpré, V. Vanhoorne, B. Van Snick, B. Blahova Prudilova, F. Detobel, JP. Remon, T. De Beer, C. Vervaet,

. 2018 ; 548 (1) : 54-61. [pub] 20180622

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19000619

Despite the high quantities of tablets produced daily, many tableting processes are still operated at sub-optimal settings and hence lack the necessary flexibility to mitigate for possible process deviations. However, to ensure this flexibility on tableting throughput it is important to select the most robust feed frame design and settings regarding die-filling. In this research study, four paddle designs for a two-compartment forced feeder (equipped with a metering and a feeding paddle wheel) were evaluated at a wide range of process-settings (i.e. tableting speed, paddle speed, overfill level) and feed frame features (i.e. deaeration) for their impact on the die-filling step of a poorly flowing model formulation (i.e. MCC 101) using a quality-by-design approach. No benefit on die-filling was observed when using higher speeds of the metering paddle wheel compared to the feeding paddle wheel, and no convincing arguments were obtained to use the feed frame deaeration opening. Some combinations of paddle design and process-settings significantly increased the risk for inconsistent die-filling (i.e. high tablet weight variability) which can therefore limit the efficiency of the tableting process. The approach used in this study enabled to compare the paddle designs for their die-filling performance in function of varying tableting speeds, eventually resulting in the selection of a feed frame design that is most robust and therefore will provide a uniform die-filling over a wide range of throughputs. Selection of the most robust parameters is an important prerequisite for the ability of using the rotary tablet press as an agile unit-operation.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000619
003      
CZ-PrNML
005      
20190121103510.0
007      
ta
008      
190107s2018 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijpharm.2018.06.047 $2 doi
035    __
$a (PubMed)29940299
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Grymonpré, W $u Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
245    10
$a Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press / $c W. Grymonpré, V. Vanhoorne, B. Van Snick, B. Blahova Prudilova, F. Detobel, JP. Remon, T. De Beer, C. Vervaet,
520    9_
$a Despite the high quantities of tablets produced daily, many tableting processes are still operated at sub-optimal settings and hence lack the necessary flexibility to mitigate for possible process deviations. However, to ensure this flexibility on tableting throughput it is important to select the most robust feed frame design and settings regarding die-filling. In this research study, four paddle designs for a two-compartment forced feeder (equipped with a metering and a feeding paddle wheel) were evaluated at a wide range of process-settings (i.e. tableting speed, paddle speed, overfill level) and feed frame features (i.e. deaeration) for their impact on the die-filling step of a poorly flowing model formulation (i.e. MCC 101) using a quality-by-design approach. No benefit on die-filling was observed when using higher speeds of the metering paddle wheel compared to the feeding paddle wheel, and no convincing arguments were obtained to use the feed frame deaeration opening. Some combinations of paddle design and process-settings significantly increased the risk for inconsistent die-filling (i.e. high tablet weight variability) which can therefore limit the efficiency of the tableting process. The approach used in this study enabled to compare the paddle designs for their die-filling performance in function of varying tableting speeds, eventually resulting in the selection of a feed frame design that is most robust and therefore will provide a uniform die-filling over a wide range of throughputs. Selection of the most robust parameters is an important prerequisite for the ability of using the rotary tablet press as an agile unit-operation.
650    _2
$a celulosa $x chemie $7 D002482
650    _2
$a příprava léků $x přístrojové vybavení $7 D004339
650    _2
$a tvrdost $7 D006244
650    _2
$a prášky, zásypy, pudry $7 D011208
650    12
$a tablety $7 D013607
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vanhoorne, V $u Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
700    1_
$a Van Snick, B $u Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
700    1_
$a Blahova Prudilova, B $u Regional Centre of Advanced Technologies and Materials, Palacky University, Olomouc, Czech Republic.
700    1_
$a Detobel, F $u GEA Process Engineering NV, Halle, Belgium.
700    1_
$a Remon, J P $u Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
700    1_
$a De Beer, T $u Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ghent, Belgium.
700    1_
$a Vervaet, C $u Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium. Electronic address: Chris.Vervaet@UGent.be.
773    0_
$w MED00002359 $t International journal of pharmaceutics $x 1873-3476 $g Roč. 548, č. 1 (2018), s. 54-61
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29940299 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20190121103728 $b ABA008
999    __
$a ok $b bmc $g 1364666 $s 1038742
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 548 $c 1 $d 54-61 $e 20180622 $i 1873-3476 $m International journal of pharmaceutics $n Int. j. pharm. $x MED00002359
LZP    __
$a Pubmed-20190107

Find record

Citation metrics

Archiving options