-
Something wrong with this record ?
Diagnostic value of serum galactomannan, (1,3)-β-d-glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients
R. Dobias, P. Jaworska, H. Tomaskova, M. Kanova, P. Lyskova, Z. Vrba, C. Holub, L. Svobodová, P. Hamal, M. Raska,
Language English Country Germany
Document type Evaluation Study, Journal Article, Multicenter Study
PubMed
29575150
DOI
10.1111/myc.12765
Knihovny.cz E-resources
- MeSH
- Aspergillus fumigatus chemistry immunology MeSH
- beta-Glucans blood MeSH
- Adult MeSH
- Immunoglobulin A blood MeSH
- Immunoglobulin G blood MeSH
- Invasive Pulmonary Aspergillosis diagnosis MeSH
- Middle Aged MeSH
- Humans MeSH
- Mannans blood MeSH
- Adolescent MeSH
- Young Adult MeSH
- Predictive Value of Tests MeSH
- Antibodies, Fungal blood MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Serum chemistry MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Multicenter Study MeSH
Detection of serum galactomannan (GM) and (1,3)-β-d-glucan (BG) is considered useful for non-culture diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Only few studies evaluated these seromarkers in non-neutropenic patients suspected of having IPA. The aim of this study was to evaluate both tests together with the Aspergillus fumigatus-specific serum IgG and IgA (IgAG) test for serological IPA diagnosis in non-neutropenic patients. Sera from 87 patients suspected of having IPA were retrospectively analysed. Patients were categorised into groups of proven IPA (n = 10), putative IPA (n = 31) and non-IPA colonisation (n = 46). When the GM, BG and IgAG assays were used for patients included in the study, the sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 48.8%/91.3%/83.3%/66.7%, 82.9%/73.9%/73.9%/82.9% and 75.6%/95.7%/93.9%/81.5%, respectively. Thus, the highest specificity and PPV were confirmed for the IgAG assay. Improvements in the sensitivity and NPV were achieved by "at least one positive" analysis with the GM and BG assays, with the sensitivity/specificity/PPV/NPV values being 85.0%/69.6%/71.4%/84.2%. Nevertheless, the highest sensitivity and NPV were achieved by the "at least one positive" analysis combining the GM, BG and IgAG tests (97.6% and 96.8%, respectively). The involvement of the IgAG assay could improve IPA diagnosis in non-neutropenic patients by increasing the sensitivity and NPV when combined with the GM or BG assays. Furthermore, improvement was achieved by combining the GM, BG and IgAG assays using the "at least one positive test" strategy, especially if doubt exists.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19000851
- 003
- CZ-PrNML
- 005
- 20211208135418.0
- 007
- ta
- 008
- 190107s2018 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/myc.12765 $2 doi
- 035 __
- $a (PubMed)29575150
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Dobias, R $u Laboratory of Clinical Mycology, Bacteriology and Mycology, Institute of Public Health in Ostrava, Ostrava, Czech Republic. Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
- 245 10
- $a Diagnostic value of serum galactomannan, (1,3)-β-d-glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients / $c R. Dobias, P. Jaworska, H. Tomaskova, M. Kanova, P. Lyskova, Z. Vrba, C. Holub, L. Svobodová, P. Hamal, M. Raska,
- 520 9_
- $a Detection of serum galactomannan (GM) and (1,3)-β-d-glucan (BG) is considered useful for non-culture diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Only few studies evaluated these seromarkers in non-neutropenic patients suspected of having IPA. The aim of this study was to evaluate both tests together with the Aspergillus fumigatus-specific serum IgG and IgA (IgAG) test for serological IPA diagnosis in non-neutropenic patients. Sera from 87 patients suspected of having IPA were retrospectively analysed. Patients were categorised into groups of proven IPA (n = 10), putative IPA (n = 31) and non-IPA colonisation (n = 46). When the GM, BG and IgAG assays were used for patients included in the study, the sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 48.8%/91.3%/83.3%/66.7%, 82.9%/73.9%/73.9%/82.9% and 75.6%/95.7%/93.9%/81.5%, respectively. Thus, the highest specificity and PPV were confirmed for the IgAG assay. Improvements in the sensitivity and NPV were achieved by "at least one positive" analysis with the GM and BG assays, with the sensitivity/specificity/PPV/NPV values being 85.0%/69.6%/71.4%/84.2%. Nevertheless, the highest sensitivity and NPV were achieved by the "at least one positive" analysis combining the GM, BG and IgAG tests (97.6% and 96.8%, respectively). The involvement of the IgAG assay could improve IPA diagnosis in non-neutropenic patients by increasing the sensitivity and NPV when combined with the GM or BG assays. Furthermore, improvement was achieved by combining the GM, BG and IgAG assays using the "at least one positive test" strategy, especially if doubt exists.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a protilátky fungální $x krev $7 D000908
- 650 _2
- $a Aspergillus fumigatus $x chemie $x imunologie $7 D001232
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunoglobulin A $x krev $7 D007070
- 650 _2
- $a imunoglobulin G $x krev $7 D007074
- 650 _2
- $a invazivní plicní aspergilóza $x diagnóza $7 D055744
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mannany $x krev $7 D008351
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a senzitivita a specificita $7 D012680
- 650 _2
- $a sérum $x chemie $7 D044967
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a beta-glukany $x krev $7 D047071
- 655 _2
- $a hodnotící studie $7 D023362
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Jaworská, Pavla $7 xx0234083 $u Laboratory of Clinical Mycology, Bacteriology and Mycology, Institute of Public Health in Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Tomaskova, H $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. Center of Health Services, Institute of Public Health in Ostrava, Ostrava, Czech Republic. Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Kanova, M $u Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic. Department of Anesthesiology and Intensive Care Medicine, University Hospital Ostrava, Ostrava, Czech Republic. Department of Intensive Medicine, Emergency Medicine and Forensic Studies, University of Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Lysková, Pavlína $7 xx0234045 $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. Laboratory of Mycology, Department of Parasitology, Mycology and Mycobacteriology Prague, Public Health Institute in Usti nad Labem, Prague, Czech Republic.
- 700 1_
- $a Vrba, Z $u Lung Department, Krnov Combined Medical Facility, Krnov, Czech Republic.
- 700 1_
- $a Holub, C $u Lung Department, Krnov Combined Medical Facility, Krnov, Czech Republic.
- 700 1_
- $a Svobodová, Lada $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. $7 xx0267259
- 700 1_
- $a Hamal, P $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
- 700 1_
- $a Raska, M $u Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
- 773 0_
- $w MED00010272 $t Mycoses $x 1439-0507 $g Roč. 61, č. 8 (2018), s. 576-586
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29575150 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20211208135417 $b ABA008
- 999 __
- $a ok $b bmc $g 1364843 $s 1038974
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 61 $c 8 $d 576-586 $e 20180611 $i 1439-0507 $m Mycoses $n Mycoses $x MED00010272
- LZP __
- $a Pubmed-20190107
