-
Je něco špatně v tomto záznamu ?
Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM
J. Pokorny, S. Krajcovicova, M. Hajduch, M. Holoubek, S. Gurska, P. Dzubak, T. Volna, I. Popa, M. Urban,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29424548
DOI
10.4155/fmc-2017-0171
Knihovny.cz E-zdroje
- MeSH
- buněčné linie MeSH
- fytogenní protinádorové látky chemická syntéza chemie farmakologie MeSH
- hydraziny chemická syntéza chemie farmakologie MeSH
- lidé MeSH
- molekulární konformace MeSH
- proliferace buněk účinky léků MeSH
- screeningové testy protinádorových léčiv MeSH
- triterpeny chemická syntéza chemie farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
AIM: From betulinic acid (1a), we synthesized 30-oxobetulinic acid (2a) that is highly cytotoxic against many cancer cell lines; however, its generic toxicity is the main obstacle in further development as cytostatic. Methodology & results: From 2a, we prepared a new class of compounds - nonsymmetrical azines and tested their in vitro cytotoxicity. All new azines with a free 28-COOH group (4a-4e) were highly and selectively cytotoxic against the T-lymphoblastic leukemia cell line CCRF-CEM and exhibited dose-dependent inhibition of RNA and DNA synthesis and other cell-cycle alterations, including the M-phase block. CONCLUSION: The potential use of azines (4a-4e) in drug development focused on hematological cancers is significantly higher than that of previously studied acids 1a and 2a.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19000926
- 003
- CZ-PrNML
- 005
- 20211209132826.0
- 007
- ta
- 008
- 190107s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.4155/fmc-2017-0171 $2 doi
- 035 __
- $a (PubMed)29424548
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Pokorny, Jan $u Department of Organic Chemistry, Faculty of Science, Palacky University in Olomouc, 17 listopadu 1192/12, 771 46 Olomouc, Czech Republic. Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 245 10
- $a Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM / $c J. Pokorny, S. Krajcovicova, M. Hajduch, M. Holoubek, S. Gurska, P. Dzubak, T. Volna, I. Popa, M. Urban,
- 520 9_
- $a AIM: From betulinic acid (1a), we synthesized 30-oxobetulinic acid (2a) that is highly cytotoxic against many cancer cell lines; however, its generic toxicity is the main obstacle in further development as cytostatic. Methodology & results: From 2a, we prepared a new class of compounds - nonsymmetrical azines and tested their in vitro cytotoxicity. All new azines with a free 28-COOH group (4a-4e) were highly and selectively cytotoxic against the T-lymphoblastic leukemia cell line CCRF-CEM and exhibited dose-dependent inhibition of RNA and DNA synthesis and other cell-cycle alterations, including the M-phase block. CONCLUSION: The potential use of azines (4a-4e) in drug development focused on hematological cancers is significantly higher than that of previously studied acids 1a and 2a.
- 650 _2
- $a fytogenní protinádorové látky $x chemická syntéza $x chemie $x farmakologie $7 D000972
- 650 _2
- $a buněčné linie $7 D002460
- 650 _2
- $a proliferace buněk $x účinky léků $7 D049109
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a screeningové testy protinádorových léčiv $7 D004354
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hydraziny $x chemická syntéza $x chemie $x farmakologie $7 D006834
- 650 _2
- $a molekulární konformace $7 D008968
- 650 _2
- $a vztahy mezi strukturou a aktivitou $7 D013329
- 650 _2
- $a triterpeny $x chemická syntéza $x chemie $x farmakologie $7 D014315
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Krajcovicova, Sona $u Department of Organic Chemistry, Faculty of Science, Palacky University in Olomouc, 17 listopadu 1192/12, 771 46 Olomouc, Czech Republic. Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Hajduch, Marian $u Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Holoubek, Martin $u Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Gurská, Soňa $u Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic. $7 xx0267298
- 700 1_
- $a Dzubak, Petr $u Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Volna, Tereza $u Department of Organic Chemistry, Faculty of Science, Palacky University in Olomouc, 17 listopadu 1192/12, 771 46 Olomouc, Czech Republic. Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Popa, Igor $u Department of Organic Chemistry, Faculty of Science, Palacky University in Olomouc, 17 listopadu 1192/12, 771 46 Olomouc, Czech Republic. Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
- 700 1_
- $a Urban, Milan $u Institute of Molecular & Translational Medicine, Faculty of Medicine & Dentistry, Palacky University in Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic. $7 xx0117688
- 773 0_
- $w MED00180228 $t Future medicinal chemistry $x 1756-8927 $g Roč. 10, č. 5 (2018), s. 483-491
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29424548 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20211209132825 $b ABA008
- 999 __
- $a ok $b bmc $g 1364897 $s 1039049
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 10 $c 5 $d 483-491 $e 20180209 $i 1756-8927 $m Future medicinal chemistry $n Future Med Chem $x MED00180228
- LZP __
- $a Pubmed-20190107
