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Intended and Unintended Targeting of Polymeric Nanocarriers: The Case of Modified Poly(glycerol adipate) Nanoparticles
VM. Weiss, H. Lucas, T. Mueller, P. Chytil, T. Etrych, T. Naolou, J. Kressler, K. Mäder,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV16-28600A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
Medline Complete (EBSCOhost)
od 2012-06-01 do Před 1 rokem
PubMed
29218838
DOI
10.1002/mabi.201700240
Knihovny.cz E-zdroje
- MeSH
- biologicky odbouratelné plasty chemie MeSH
- buňky HT-29 MeSH
- fluorescenční barviva chemie MeSH
- lékové transportní systémy * MeSH
- lidé MeSH
- methakryláty aplikace a dávkování chemie MeSH
- myši MeSH
- nádory farmakoterapie genetika patologie MeSH
- nanočástice aplikace a dávkování chemie MeSH
- nosiče léků aplikace a dávkování chemie MeSH
- polyestery aplikace a dávkování chemie MeSH
- tkáňová distribuce účinky léků MeSH
- xenogenní modely - testy protinádorové aktivity MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Biodegradable nanoparticles based on stearic acid-modified poly(glycerol adipate) (PGAS) are promising carriers for drug delivery. In order to investigate the impact of the particle interface characteristics on the biological fate, PGAS nanoparticles are covalently and noncovalently coated with N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers. HPMA copolymer-modified PGAS nanoparticles have similar particle sizes, but less negative zeta-potentials. Nanoparticles are double labeled with the fluorescent dyes DiR (noncovalently) and DYOMICS-676 (covalently bound to HPMA copolymer), and their biodistribution is investigated noninvasively by multispectral optical imaging. Both covalent and noncovalent coatings cause changes in the pharmacokinetics and biodistribution in healthy and tumor-bearing mice. In addition to the intended tumor accumulation, high signals of both fluorescent dyes are also observed in other organs, including liver, ovaries, adrenal glands, and bone. The unintended accumulation of nanocarriers needs further detailed and systematic investigations, especially with respect to the observed ovarian and adrenal gland accumulation.
Department of Biomimetic Materials Institute of Biomaterial Science HZG Teltow 14513 Teltow Germany
Department of Internal Medicine 4 Germany
Institute of Chemistry Martin Luther University Halle Wittenberg 06120 Halle Germany
Institute of Macromolecular Chemistry Czech Academy of Science 162 06 Prague 6 Czech Republic
Institute of Pharmacy Martin Luther University Halle Wittenberg 06120 Halle Germany
Citace poskytuje Crossref.org
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