-
Je něco špatně v tomto záznamu ?
The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo
K. Lněničková, H. Svobodová, L. Skálová, M. Ambrož, F. Novák, P. Matoušková,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- MeSH
- aldehydreduktasa metabolismus MeSH
- enzymy metabolismus MeSH
- estradioldehydrogenasy metabolismus MeSH
- inbrední kmeny myší MeSH
- játra účinky léků enzymologie MeSH
- metabolická inaktivace účinky léků MeSH
- NAD(P)H dehydrogenasa (chinon) metabolismus MeSH
- regulace genové exprese enzymů účinky léků MeSH
- seskviterpeny farmakologie toxicita MeSH
- systém (enzymů) cytochromů P-450 genetika metabolismus MeSH
- tenké střevo účinky léků enzymologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
1. Sesquiterpenes, constituents of plant essential oil, are popular bioactive compounds due to the positive effect on human health, but their potential toxicity and possible herb-drug interactions are often omitted. In our in vivo study, we followed up the effect of p.o. administration of two sesquiterpenes β-caryophyllene oxide (CAO) and trans-nerolidol (NER) on various xenobiotic-metabolizing enzymes in mice liver and small intestine. 2. To spot the early effect of studied compounds, enzymatic activity and mRNA levels were assessed 6 and 24 h after single dose. 3. CAO and NER markedly increased cytochromes P450 (CYP2B, 3A, 2C) activity and mRNA levels in both tissues. Liver also showed elevated activity of aldo-ketoreductase 1C and carbonyl reductase after treatment. Contrary, sesquiterpenes decreased NAD(P)H:quinone oxidoreductase 1 activity in small intestine. Among conjugation enzymes, only liver sulfotransferase activity was increased by sesquiterpenes. 4. Our results document that single dose of sesquiterpenes modulate activities and expression of several xenobiotic-metabolizing enzymes.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19001116
- 003
- CZ-PrNML
- 005
- 20221013141950.0
- 007
- ta
- 008
- 190107s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/00498254.2017.1398359 $2 doi
- 035 __
- $a (PubMed)29098926
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Lněničková, Kateřina $u a Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic. $7 xx0267222
- 245 14
- $a The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo / $c K. Lněničková, H. Svobodová, L. Skálová, M. Ambrož, F. Novák, P. Matoušková,
- 520 9_
- $a 1. Sesquiterpenes, constituents of plant essential oil, are popular bioactive compounds due to the positive effect on human health, but their potential toxicity and possible herb-drug interactions are often omitted. In our in vivo study, we followed up the effect of p.o. administration of two sesquiterpenes β-caryophyllene oxide (CAO) and trans-nerolidol (NER) on various xenobiotic-metabolizing enzymes in mice liver and small intestine. 2. To spot the early effect of studied compounds, enzymatic activity and mRNA levels were assessed 6 and 24 h after single dose. 3. CAO and NER markedly increased cytochromes P450 (CYP2B, 3A, 2C) activity and mRNA levels in both tissues. Liver also showed elevated activity of aldo-ketoreductase 1C and carbonyl reductase after treatment. Contrary, sesquiterpenes decreased NAD(P)H:quinone oxidoreductase 1 activity in small intestine. Among conjugation enzymes, only liver sulfotransferase activity was increased by sesquiterpenes. 4. Our results document that single dose of sesquiterpenes modulate activities and expression of several xenobiotic-metabolizing enzymes.
- 650 _2
- $a aldehydreduktasa $x metabolismus $7 D000449
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a systém (enzymů) cytochromů P-450 $x genetika $x metabolismus $7 D003577
- 650 _2
- $a enzymy $x metabolismus $7 D004798
- 650 _2
- $a estradioldehydrogenasy $x metabolismus $7 D004960
- 650 _2
- $a regulace genové exprese enzymů $x účinky léků $7 D015971
- 650 _2
- $a metabolická inaktivace $x účinky léků $7 D008658
- 650 _2
- $a tenké střevo $x účinky léků $x enzymologie $7 D007421
- 650 _2
- $a játra $x účinky léků $x enzymologie $7 D008099
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a inbrední kmeny myší $7 D008815
- 650 _2
- $a NAD(P)H dehydrogenasa (chinon) $x metabolismus $7 D016660
- 650 _2
- $a seskviterpeny $x farmakologie $x toxicita $7 D012717
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Svobodová, Hana $u a Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic.
- 700 1_
- $a Skálová, Lenka $u a Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic.
- 700 1_
- $a Ambrož, Martin $u Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic. $7 xx0277534
- 700 1_
- $a Novák, Filip $u a Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic.
- 700 1_
- $a Matoušková, Petra $u a Faculty of Pharmacy, Charles University , Hradec Králové , Czech Republic.
- 773 0_
- $w MED00004746 $t Xenobiotica $x 1366-5928 $g Roč. 48, č. 11 (2018), s. 1089-1097
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29098926 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20221013141944 $b ABA008
- 999 __
- $a ok $b bmc $g 1365037 $s 1039239
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 48 $c 11 $d 1089-1097 $e 20171110 $i 1366-5928 $m Xenobiotica $n Xenobiotica $x MED00004746
- LZP __
- $a Pubmed-20190107
