• Je něco špatně v tomto záznamu ?

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

F. Roth-Walter, C. Bergmayr, S. Meitz, S. Buchleitner, C. Stremnitzer, J. Fazekas, A. Moskovskich, MA. Müller, GA. Roth, K. Manzano-Szalai, Z. Dvorak, A. Neunkirchner, E. Jensen-Jarolim,

. 2017 ; 7 (-) : 45067. [pub] 20170323

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19001288

Acrolein, a highly reactive unsaturated aldehyde, is generated in large amounts during smoking and is best known for its genotoxic capacity. Here, we aimed to assess whether acrolein at concentrations relevant for smokers may also exert immunomodulatory effects that could be relevant in allergy or cancer. In a BALB/c allergy model repeated nasal exposure to acrolein abrogated allergen-specific antibody and cytokine formation, and led to a relative accumulation of regulatory T cells in the lungs. Only the acrolein-treated mice were protected from bronchial hyperreactivity as well as from anaphylactic reactions upon challenge with the specific allergen. Moreover, grafted D2F2 tumor cells grew faster and intratumoral Foxp3+ cell accumulation was observed in these mice compared to sham-treated controls. Results from reporter cell lines suggested that acrolein acts via the aryl-hydrocarbon receptor which could be inhibited by resveratrol and 3'-methoxy-4'-nitroflavone Acrolein- stimulation of human PBMCs increased Foxp3+ expression by T cells which could be antagonized by resveratrol. Our mouse and human data thus revealed that acrolein exerts systemic immunosuppression by promoting Foxp3+ regulatory cells. This provides a novel explanation why smokers have a lower allergy, but higher cancer risk.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19001288
003      
CZ-PrNML
005      
20200121142024.0
007      
ta
008      
190107s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/srep45067 $2 doi
035    __
$a (PubMed)28332605
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Roth-Walter, Franziska $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
245    10
$a Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure / $c F. Roth-Walter, C. Bergmayr, S. Meitz, S. Buchleitner, C. Stremnitzer, J. Fazekas, A. Moskovskich, MA. Müller, GA. Roth, K. Manzano-Szalai, Z. Dvorak, A. Neunkirchner, E. Jensen-Jarolim,
520    9_
$a Acrolein, a highly reactive unsaturated aldehyde, is generated in large amounts during smoking and is best known for its genotoxic capacity. Here, we aimed to assess whether acrolein at concentrations relevant for smokers may also exert immunomodulatory effects that could be relevant in allergy or cancer. In a BALB/c allergy model repeated nasal exposure to acrolein abrogated allergen-specific antibody and cytokine formation, and led to a relative accumulation of regulatory T cells in the lungs. Only the acrolein-treated mice were protected from bronchial hyperreactivity as well as from anaphylactic reactions upon challenge with the specific allergen. Moreover, grafted D2F2 tumor cells grew faster and intratumoral Foxp3+ cell accumulation was observed in these mice compared to sham-treated controls. Results from reporter cell lines suggested that acrolein acts via the aryl-hydrocarbon receptor which could be inhibited by resveratrol and 3'-methoxy-4'-nitroflavone Acrolein- stimulation of human PBMCs increased Foxp3+ expression by T cells which could be antagonized by resveratrol. Our mouse and human data thus revealed that acrolein exerts systemic immunosuppression by promoting Foxp3+ regulatory cells. This provides a novel explanation why smokers have a lower allergy, but higher cancer risk.
650    _2
$a akrolein $x farmakologie $7 D000171
650    _2
$a alergeny $x imunologie $7 D000485
650    _2
$a zvířata $7 D000818
650    _2
$a tvorba protilátek $x imunologie $7 D000917
650    _2
$a cytokiny $x metabolismus $7 D016207
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a forkhead transkripční faktory $x metabolismus $7 D051858
650    _2
$a alergie $x imunologie $x prevence a kontrola $7 D006967
650    _2
$a imunologické faktory $x farmakologie $7 D007155
650    _2
$a plíce $x imunologie $x metabolismus $x patologie $7 D008168
650    _2
$a myši $7 D051379
650    _2
$a NF-kappa B $x metabolismus $7 D016328
650    _2
$a nádory $x imunologie $x metabolismus $7 D009369
650    _2
$a receptory aromatických uhlovodíků $x metabolismus $7 D018336
650    _2
$a resveratrol $7 D000077185
650    _2
$a signální transdukce $7 D015398
650    _2
$a stilbeny $x farmakologie $7 D013267
650    _2
$a regulační T-lymfocyty $x imunologie $x metabolismus $7 D050378
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Bergmayr, Cornelia $u Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
700    1_
$a Meitz, Sarah $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Buchleitner, Stefan $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Stremnitzer, Caroline $u Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
700    1_
$a Fazekas, Judit $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Moskovskich, Anna $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Müller, Mario A $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Roth, Georg A $u Department of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Austria.
700    1_
$a Manzano-Szalai, Krisztina $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
700    1_
$a Dvorak, Zdenek $u Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic.
700    1_
$a Neunkirchner, Alina $u Christian Doppler Laboratory for Immunomodulation, Medical University of Vienna, Vienna, Austria.
700    1_
$a Jensen-Jarolim, Erika $u Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria. Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 7, č. - (2017), s. 45067
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28332605 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20200121142401 $b ABA008
999    __
$a ok $b bmc $g 1365174 $s 1039411
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 7 $c - $d 45067 $e 20170323 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20190107

Najít záznam

Citační ukazatele

Možnosti archivace