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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
A. Ferreiro-Iglesias, C. Lesseur, J. McKay, RJ. Hung, Y. Han, X. Zong, D. Christiani, M. Johansson, X. Xiao, Y. Li, DC. Qian, X. Ji, G. Liu, N. Caporaso, G. Scelo, D. Zaridze, A. Mukeriya, M. Kontic, S. Ognjanovic, J. Lissowska, M. Szołkowska, B....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
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Directory of Open Access Journals
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Free Medical Journals
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od 2010-01-01
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- MeSH
- Asijci genetika MeSH
- běloši genetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci etnologie genetika MeSH
- genotyp MeSH
- HLA antigeny genetika MeSH
- hlavní histokompatibilní komplex genetika MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mapování chromozomů * MeSH
- nádory plic etnologie genetika MeSH
- peptidy genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
Biomedical Data Science Geisel School of Medicine at Dartmouth Hanover 03755 NH USA
British Columbia Cancer Agency Vancouver V5Z 1M9 Canada
Clinical Center of Serbia Belgrade 11000 Serbia
Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz 91 348 Poland
Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston 77030 TX USA
Department of Medical Biosciences Umeå University Umeå 901 85 Sweden
Department of Oncology University of Sheffield Sheffield S10 2RX UK
Department of Radiation Sciences Umeå University Umeå 901 85 Sweden
Department of Thoracic Surgery Clinical Center of Serbia Belgrade Belgrade 11000 Serbia
Epidemiology Program University of Hawaii Cancer Center Honolulu 96813 HI USA
Faculty of Medicine University of Olomouc Olomouc 701 03 Czech Republic
Institute of Pneumology Marius Nasta Bucharest RO 050159 Romania
Institute of Translational Medicine University of Liverpool Liverpool L3 9TA UK
International Agency for Research on Cancer World Health Organization Lyon 69372 cedex 08 France
International Organization for Cancer Prevention and Research Belgrade 11070 Serbia
M Sklodowska Curie Cancer Center Institute of Oncology Warsaw 02 034 Poland
National Institute of Occupational Health Oslo N 0033 Norway
Princess Margaret Cancer Centre Toronto ON M5G 1L7 Canada
Radboud University Medical Center Nijmegen 9500 The Netherlands
Russian N N Blokhin Cancer Research Centre Moscow 115478 Russian Federation
School of Health and Related Research University Of Sheffield England S1 4DA UK
Swedish Medical Group Seattle 98104 WA USA
Unit of Nutrition and Cancer Catalan Institute of Oncology Barcelona 08908 Spain
University of Kentucky Markey Cancer Center Lexington 40536 0098 KY USA
University of Oviedo and CIBERESP Faculty of Medicine Oviedo 33006 Spain
University of Pittsburgh Cancer Institute Pittsburgh 15232 PA USA
Citace poskytuje Crossref.org
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