• Je něco špatně v tomto záznamu ?

Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study

S. Chetcuti Zammit, P. Ellul, G. Girardin, D. Valpiani, KR. Nielsen, J. Olsen, A. Goldis, D. Lazar, O. Shonová, M. Nováková, S. Sebastian, E. Whitehead, A. Carmona, J. Martinez-Cadilla, JF. Dahlerup, ALH. Kievit, N. Thorsgaard, KH. Katsanos, DK....

. 2018 ; 30 (11) : 1297-1303.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012444

BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing. MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores. RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053). CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.

Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania Balkans

Department of Gastroenterology Adelaide and Meath Hospital TCD Dublin Ireland

Department of Gastroenterology and Hepatology Soroka Medical Centre Ben Gurion University of the Negev Faculty of Health Sciences Beer Sheva Israel

Department of Gastroenterology Faculty of Medicine and Health Örebro University Örebro

Department of Gastroenterology Hospital Povisa Vigo

Department of Gastroenterology Instituto de Investigación Biomédica Galicia Sur Estrutura Organizativa de Xestión Integrada de Vigo Spain

Department of Gastroenterology Medical Academy Lithuanian University of Health Sciences Kaunas Lithuania

Department of Gastroenterology North Zealand University Hospital Roskilde Denmark

Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus

Department of Medicine Solna Karolinska Institutet Center for Digestive Diseases Karolinska University Hospital Stockholm Sweden

Department of Pediatrics Hvidovre Hospital University of Copenhagen Hvidovre

Department of Surgical Oncological and Gastroenterological Sciences University of Padua Padua

Division of Gastroenterology Medical School and University Hospital of Ioannina Greece

Focused Research Unit for Molecular Diagnostic and Clinical Research IRS Center Sonderjylland Hospital of Southern Jutland Aabenraa

Gastroenterology Department Hospital São João Institute of Pharmacology and Therapeutics Faculty of Medicine of the University of Porto Porto Portugal

Gastroenterology Department Odense University Hospital Odense C

Gastroenterology Department Slagelse Hospital Slagelse

Gastroenterology Division Mater Dei Hospital Malta

Herning

Hospital Budweis South Bohemia

IBD Clinical and Research Centre Iscare Prague Czech Republic

IBD Department St Mark's Hospital London UK

IBD Unit Hull and East Yorkshire NHS Trust

Medical Department The National Hospital of the Faroe Islands Torshavn Faroe Islands

Medical Department Viborg Regional Hospital Viborg

Nicosia Private Practice Cyprus

Pekka Collin Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere Finland

Semmelweis University Budapest Hungary

Tartu University Hospital University of Tartu Tartu Estonia

U O Gastroenterologia ed Endoscopia Digestiva Ospedale Morgagni Pierantoni Forlì Italy

University Hospital Center Zagreb School of Medicine University of Zagreb Zagreb Croatia

000      
00000naa a2200000 a 4500
001      
bmc19012444
003      
CZ-PrNML
005      
20200310083635.0
007      
ta
008      
190405s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1097/MEG.0000000000001238 $2 doi
035    __
$a (PubMed)30134383
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Chetcuti Zammit, Stefania $u Gastroenterology Division, Mater Dei Hospital, Malta.
245    10
$a Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study / $c S. Chetcuti Zammit, P. Ellul, G. Girardin, D. Valpiani, KR. Nielsen, J. Olsen, A. Goldis, D. Lazar, O. Shonová, M. Nováková, S. Sebastian, E. Whitehead, A. Carmona, J. Martinez-Cadilla, JF. Dahlerup, ALH. Kievit, N. Thorsgaard, KH. Katsanos, DK. Christodoulou, F. Magro, R. Salupere, N. Pedersen, J. Kjeldsen, K. Carlsen, K. Ioannis, D. Bergemalm, J. Halfvarson, D. Duricova, M. Bortlik, P. Collin, P. Oksanen, G. Kiudelis, L. Kupcinskas, K. Kudsk, V. Andersen, C. O'Morain, Y. Bailey, S. Doron, O. Shmuel, S. Almer, N. Arebi, R. Misra, S. Čuković-Čavka, M. Brinar, P. Munkholm, Z. Vegh, J. Burisch,
520    9_
$a BACKGROUND: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing. MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores. RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053). CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.
650    _2
$a mladiství $7 D000293
650    _2
$a hormony kůry nadledvin $x terapeutické užití $7 D000305
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a antiflogistika $x terapeutické užití $7 D000893
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a dítě $7 D002648
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a idiopatické střevní záněty $x diagnóza $x farmakoterapie $x epidemiologie $7 D015212
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prevalence $7 D015995
650    _2
$a kvalita života $7 D011788
650    _2
$a rizikové faktory $7 D012307
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a kouření $x škodlivé účinky $x krev $x epidemiologie $7 D012907
650    _2
$a časové faktory $7 D013997
650    _2
$a vitamin D $x krev $7 D014807
650    _2
$a nedostatek vitaminu D $x krev $x diagnóza $x epidemiologie $7 D014808
650    _2
$a mladý dospělý $7 D055815
651    _2
$a Evropa $x epidemiologie $7 D005060
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Ellul, Pierre $u Gastroenterology Division, Mater Dei Hospital, Malta.
700    1_
$a Girardin, Giulia $u Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua.
700    1_
$a Valpiani, Daniela $u U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni, Pierantoni, Forlì, Italy.
700    1_
$a Nielsen, Kári R $u Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
700    1_
$a Olsen, Jóngerð $u Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
700    1_
$a Goldis, Adrian $u Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania, Balkans.
700    1_
$a Lazar, Daniela $u Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania, Balkans.
700    1_
$a Shonová, Olga $u Hospital Budweis, South Bohemia.
700    1_
$a Nováková, Marie $u Hospital Budweis, South Bohemia.
700    1_
$a Sebastian, Shaji $u IBD Unit, Hull and East Yorkshire NHS Trust.
700    1_
$a Whitehead, Emma $u IBD Unit, Hull and East Yorkshire NHS Trust.
700    1_
$a Carmona, Amalia $u Department of Gastroenterology, Hospital Povisa, Vigo.
700    1_
$a Martinez-Cadilla, Jesus $u Department of Gastroenterology, Instituto de Investigación Biomédica Galicia Sur. Estrutura Organizativa de Xestión Integrada de Vigo, Spain.
700    1_
$a Dahlerup, Jens F $u Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus.
700    1_
$a Kievit, Adriana L H $u Herning.
700    1_
$a Thorsgaard, Niels $u Herning.
700    1_
$a Katsanos, Konstantinos H $u Division of Gastroenterology, Medical School and University Hospital of Ioannina, Greece.
700    1_
$a Christodoulou, Dimitrios K $u Division of Gastroenterology, Medical School and University Hospital of Ioannina, Greece.
700    1_
$a Magro, Fernando $u Gastroenterology Department, Hospital São João. Institute of Pharmacology and Therapeutics Faculty of Medicine of the University of Porto, Porto, Portugal.
700    1_
$a Salupere, Riina $u Tartu University Hospital, University of Tartu, Tartu, Estonia.
700    1_
$a Pedersen, Natalia $u Gastroenterology Department Slagelse Hospital, Slagelse.
700    1_
$a Kjeldsen, Jens $u Gastroenterology Department, Odense University Hospital, Odense C.
700    1_
$a Carlsen, Katrine $u Department of Pediatrics, Hvidovre Hospital, University of Copenhagen, Hvidovre.
700    1_
$a Ioannis, Kaimaklioti $u Nicosia Private Practice, Cyprus.
700    1_
$a Bergemalm, Daniel $u Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro.
700    1_
$a Halfvarson, Jonas, $d 1970- $7 xx0245713 $u Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro.
700    1_
$a Duricova, Dana $u IBD Clinical and Research Centre Iscare, Prague, Czech Republic.
700    1_
$a Bortlik, Martin $u IBD Clinical and Research Centre Iscare, Prague, Czech Republic.
700    1_
$a Collin, Pekka $u Pekka Collin Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
700    1_
$a Oksanen, Pia $u Pekka Collin Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
700    1_
$a Kiudelis, Gediminas $u Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
700    1_
$a Kupcinskas, Limas $u Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
700    1_
$a Kudsk, Karen $u Medical Department, Viborg Regional Hospital, Viborg.
700    1_
$a Andersen, Vibeke $u Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa.
700    1_
$a O'Morain, Colm $u Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
700    1_
$a Bailey, Yvonne $u Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
700    1_
$a Doron, Schwartz $u Department of Gastroenterology and Hepatology, Soroka Medical Centre, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel.
700    1_
$a Shmuel, Odes $u Department of Gastroenterology and Hepatology, Soroka Medical Centre, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel.
700    1_
$a Almer, Sven $u Department of Medicine, Solna, Karolinska Institutet. Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
700    1_
$a Arebi, Naila $u IBD Department St Mark's Hospital, London, UK.
700    1_
$a Misra, Ravi $u IBD Department St Mark's Hospital, London, UK.
700    1_
$a Čuković-Čavka, Silvija $u University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
700    1_
$a Brinar, Marko $u University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
700    1_
$a Munkholm, Pia $u Department of Gastroenterology, North Zealand University Hospital, Roskilde, Denmark.
700    1_
$a Vegh, Zsuzsanna $u Semmelweis University, Budapest, Hungary.
700    1_
$a Burisch, Johan $u Department of Gastroenterology, North Zealand University Hospital, Roskilde, Denmark.
773    0_
$w MED00001618 $t European journal of gastroenterology & hepatology $x 1473-5687 $g Roč. 30, č. 11 (2018), s. 1297-1303
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30134383 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20200310084053 $b ABA008
999    __
$a ok $b bmc $g 1391754 $s 1050749
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 30 $c 11 $d 1297-1303 $i 1473-5687 $m European journal of gastroenterology & hepatology $n Eur J Gastroenterol Hepatol $x MED00001618
LZP    __
$a Pubmed-20190405

Najít záznam

Citační ukazatele

Možnosti archivace