-
Je něco špatně v tomto záznamu ?
Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese
M. Siklova, M. Koc, L. Rossmeislová, P. Kraml,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 2005 do Před 5 lety
ProQuest Central
od 2005-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2005-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2005-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
29081508
DOI
10.1038/ijo.2017.260
Knihovny.cz E-zdroje
- MeSH
- beta-2-glykoprotein I krev chemie metabolismus MeSH
- biologické markery krev MeSH
- dospělí MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipoproteiny LDL krev chemie metabolismus MeSH
- metabolický syndrom krev patofyziologie MeSH
- multiproteinové komplexy MeSH
- obezita * krev metabolismus patofyziologie MeSH
- tuková tkáň metabolismus patofyziologie MeSH
- zánět krev patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND/OBJECTIVES: OxLDL-β2GPI complex has been suggested to have a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development. SUBJECTS/METHODS: Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of body mass index (17-48 kg m-2) and metabolic status (with or without metabolic syndrome (MS); cohort II: 20 obese women undergoing a dietary intervention (DI) consisting of 1-month very-low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL-β2GPI were measured by enzyme-linked immunosorbent assay. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and homeostasis model assessment of insulin resistance. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in cohort I and in SAT in cohort II. RESULTS: Serum oxLDL-β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6±5.0 vs lean: 15.17±1.97, P<0.001; vs obese without MS: 16.36±2.89, P<0.05). Serum oxLDL-β2GPI correlated with MS indices (glucose, high-density lipoprotein, triglyceride and ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing DI decreased serum oxLDL-β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT. CONCLUSIONS: OxLDL-β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19013040
- 003
- CZ-PrNML
- 005
- 20190412101738.0
- 007
- ta
- 008
- 190405s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/ijo.2017.260 $2 doi
- 035 __
- $a (PubMed)29081508
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Siklova, M $u Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, and Institut des Maladies Métaboliques et Cardiovasculaires, Université Toulouse III Paul Sabatier, Toulouse, France.
- 245 10
- $a Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese / $c M. Siklova, M. Koc, L. Rossmeislová, P. Kraml,
- 520 9_
- $a BACKGROUND/OBJECTIVES: OxLDL-β2GPI complex has been suggested to have a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL-β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development. SUBJECTS/METHODS: Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of body mass index (17-48 kg m-2) and metabolic status (with or without metabolic syndrome (MS); cohort II: 20 obese women undergoing a dietary intervention (DI) consisting of 1-month very-low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL-β2GPI were measured by enzyme-linked immunosorbent assay. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and homeostasis model assessment of insulin resistance. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in cohort I and in SAT in cohort II. RESULTS: Serum oxLDL-β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6±5.0 vs lean: 15.17±1.97, P<0.001; vs obese without MS: 16.36±2.89, P<0.05). Serum oxLDL-β2GPI correlated with MS indices (glucose, high-density lipoprotein, triglyceride and ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing DI decreased serum oxLDL-β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT. CONCLUSIONS: OxLDL-β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.
- 650 _2
- $a tuková tkáň $x metabolismus $x patofyziologie $7 D000273
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a biologické markery $x krev $7 D015415
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a zánět $x krev $x patofyziologie $7 D007249
- 650 _2
- $a lipoproteiny LDL $x krev $x chemie $x metabolismus $7 D008077
- 650 _2
- $a metabolický syndrom $x krev $x patofyziologie $7 D024821
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a multiproteinové komplexy $7 D046912
- 650 12
- $a obezita $x krev $x metabolismus $x patofyziologie $7 D009765
- 650 _2
- $a beta-2-glykoprotein I $x krev $x chemie $x metabolismus $7 D053482
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Koc, M $u Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, and Institut des Maladies Métaboliques et Cardiovasculaires, Université Toulouse III Paul Sabatier, Toulouse, France.
- 700 1_
- $a Rossmeislová, L $u Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, and Institut des Maladies Métaboliques et Cardiovasculaires, Université Toulouse III Paul Sabatier, Toulouse, France.
- 700 1_
- $a Kraml, P $u Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, and Institut des Maladies Métaboliques et Cardiovasculaires, Université Toulouse III Paul Sabatier, Toulouse, France.
- 773 0_
- $w MED00009902 $t International journal of obesity (2005) $x 1476-5497 $g Roč. 42, č. 3 (2018), s. 405-411
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29081508 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190405 $b ABA008
- 991 __
- $a 20190412101757 $b ABA008
- 999 __
- $a ok $b bmc $g 1392350 $s 1051345
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 42 $c 3 $d 405-411 $e 20171030 $i 1476-5497 $m International journal of obesity $n Int J Obes (Lond) $x MED00009902
- LZP __
- $a Pubmed-20190405
