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Immunohistochemical Evidence of the Involvement of Natural Killer (CD161+) Cells in Spontaneous Regression of Lewis Rat Sarcoma

J. Kovalska, M. Cervinkova, E. Chmelikova, D. Planska, J. Cizkova, V. Horak,

. 2019 ; 33 (1) : 47-52. [pub] -

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19027959

BACKGROUND/AIM: Spontaneous regression (SR) of tumours is a rare phenomenon not yet fully understood. The aim of this study was to investigate immune cells infiltrating progressive and SR tumours in a Lewis rat sarcoma model. MATERIALS AND METHODS: Rats were subcutaneously inoculated with rat sarcoma R5-28 (clone C4) cells. Developing tumours were obtained on day 42 and cryosections were immunohistochemically processed for detection of immune cells. RESULTS: A high density of granulocytes was found in the necrotic areas of both progressive and SR tumours. CD4+ cells and CD8+ cells were rare and sparsely dispersed in the tumour tissue without clear difference between the two types of tumours. On the contrary, CD161+ cells were abundant and evenly distributed in SR tumours, but these cells were very rare in progressive tumours. CONCLUSION: Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161+) cells play a major role in the destruction of cancer cells during SR of tumours in this Lewis rat model.

Citace poskytuje Crossref.org

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$a Cervinkova, Monika $u Institute of Animal Physiology and Genetics, the Czech Academy of Sciences, Libechov, Czech Republic. Department of Surgery, First Medical Faculty of Charles University, Hospital Na Bulovce, Prague, Czech Republic.
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$a Chmelikova, Eva $u Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague, Czech Republic.
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$a Planska, Daniela $u Institute of Animal Physiology and Genetics, the Czech Academy of Sciences, Libechov, Czech Republic.
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