BACKGROUND/AIM: Spontaneous regression (SR) of tumours is a rare phenomenon not yet fully understood. The aim of this study was to investigate immune cells infiltrating progressive and SR tumours in a Lewis rat sarcoma model. MATERIALS AND METHODS: Rats were subcutaneously inoculated with rat sarcoma R5-28 (clone C4) cells. Developing tumours were obtained on day 42 and cryosections were immunohistochemically processed for detection of immune cells. RESULTS: A high density of granulocytes was found in the necrotic areas of both progressive and SR tumours. CD4+ cells and CD8+ cells were rare and sparsely dispersed in the tumour tissue without clear difference between the two types of tumours. On the contrary, CD161+ cells were abundant and evenly distributed in SR tumours, but these cells were very rare in progressive tumours. CONCLUSION: Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161+) cells play a major role in the destruction of cancer cells during SR of tumours in this Lewis rat model.
- MeSH
- buňky NK patologie MeSH
- CD4-pozitivní T-lymfocyty patologie MeSH
- CD8-pozitivní T-lymfocyty patologie MeSH
- imunohistochemie MeSH
- krysa rodu rattus MeSH
- lektinové receptory NK-buněk - podrodina B genetika MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- potkani inbrední LEW MeSH
- regulace genové exprese u nádorů MeSH
- sarkom genetika patologie MeSH
- spontánní regrese nádoru genetika patologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
