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Porphyrin‑silver nanoparticles hybrids: Synthesis, characterization and antibacterial activity
R. Elashnikov, M. Radocha, I. Panov, S. Rimpelova, P. Ulbrich, A. Michalcova, V. Svorcik, O. Lyutakov,
Language English Country Netherlands
Document type Journal Article
- MeSH
- Anti-Bacterial Agents chemical synthesis pharmacology MeSH
- Escherichia coli drug effects MeSH
- Metal Nanoparticles chemistry ultrastructure MeSH
- Luminescence MeSH
- Microbial Sensitivity Tests MeSH
- Porphyrins chemical synthesis chemistry pharmacology MeSH
- Staphylococcus epidermidis drug effects MeSH
- Silver chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
The preparation of light-activated hybrid antibacterial agent combining the porphyrin molecules, bound to the silver nanoparticles (AgNPs) surface is reported. AgNPs were synthesized by N-methyl-2-pyrrolidone-initiated reduction without additional reducing agents. The chemical structure of protoporphyrin IX was modified with the aim to introduce thiol groups. The size distribution and shape features of AgNPs were checked using TEM and HRTEM microscopies. The introduction of thiol groups into the porphyrin was proved by IR spectroscopy. The AgNPs-porphyrin binding was performed in solution and confirmed by fluorescence quenching, Raman spectroscopy and energy-filtered transmission electron microscopy (EFTEM). The antibacterial tests were performed against S. epidermidis and E. coli upon to LED illumination and in the dark. The synergetic effect of AgNPs and porphyrin as well as light activation of the created antibacterial conjugates were observed.
Department of Solid State Engineering University of Chemistry and Technology Prague Czech Republic
Institute of Chemical Process Fundamentals of the CAS v v i Prague Czech Republic
References provided by Crossref.org
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