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Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study
R. Shroff, C. Smith, B. Ranchin, AK. Bayazit, CJ. Stefanidis, V. Askiti, K. Azukaitis, N. Canpolat, A. Ağbaş, H. Aitkenhead, A. Anarat, B. Aoun, D. Aofolaju, SA. Bakkaloglu, D. Bhowruth, D. Borzych-Dużałka, IK. Bulut, R. Büscher, J. Deanfield, C....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie, pozorovací studie
NLK
Free Medical Journals
od 1990 do Před 1 rokem
PubMed Central
od 2008 do Před 1 rokem
Europe PubMed Central
od 2008 do Před 1 rokem
Open Access Digital Library
od 1990-07-01
PubMed
30846560
DOI
10.1681/asn.2018100990
Knihovny.cz E-zdroje
- MeSH
- beta-2-mikroglobulin krev MeSH
- bolesti hlavy etiologie MeSH
- C-reaktivní protein MeSH
- chronické selhání ledvin krev komplikace terapie MeSH
- dialýza ledvin škodlivé účinky MeSH
- dítě MeSH
- fosfáty krev MeSH
- hemodiafiltrace * škodlivé účinky metody MeSH
- hemoglobiny metabolismus MeSH
- hodnocení výsledků péče pacientem MeSH
- hospitalizace MeSH
- hypertenze etiologie MeSH
- intimomediální šíře tepenné stěny * MeSH
- krevní tlak MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- parathormon krev MeSH
- předškolní dítě MeSH
- svalové křeče etiologie MeSH
- tělesná výška * MeSH
- závrať etiologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- srovnávací studie MeSH
BACKGROUND: Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. METHODS: The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. RESULTS: We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher β2-microglobulin. The HDF cohort had lower β2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. CONCLUSIONS: HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.
Nephrology Unit Armand Trousseau Hospital Paris France
Nephrology Unit Bambino Gesù Children Research Hospital Rome Italy
Nephrology Unit Center for Pediatrics and Adolescent Medicine Heidelberg Germany
Nephrology Unit Cerrahpasa School of Medicine Istanbul Turkey
Nephrology Unit Children's Dialysis Center Strasbourg France
Nephrology Unit Children's Memorial Health Institute Warsaw Poland
Nephrology Unit Clinic of Pediatrics Vilnius University Vilnius Lithuania
Nephrology Unit Cukurova University Adana Turkey
Nephrology Unit Ege University Faculty of Medicine Izmir Turkey
Nephrology Unit Fondazione Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Nephrology Unit Gazi University Hospital Ankara Turkey
Nephrology Unit Hacettepe University Ankara Turkey
Nephrology Unit Hôpital Jeanne De Flandre Lille Cedex France
Nephrology Unit Hôpital Necker Enfants Malades Paris France
Nephrology Unit Istanbul University Faculty of Medicine Istanbul Turkey
Nephrology Unit Kings College London Evelina London Children's Hospital London United Kingdom
Nephrology Unit Kyriakou Children's Hospital Athens Greece
Nephrology Unit Medical University of Gdansk Gdansk Poland
Nephrology Unit Pediatric Dialysis and Transplant Unit Padova Italy
Nephrology Unit Royal Manchester Children's Hospital Manchester United Kingdom
Nephrology Unit The Hospital for Sick Children Toronto Canada
Nephrology Unit University Children Hospital Essen Essen Germany
Nephrology Unit University Children's Hospital Belgrade Serbia
Nephrology Unit University Hospital Cologne Cologne Germany
Nephrology Unit University Hospital Motol Prague Czech Republic
Nephrology Unit University Hospital of Wales Cardiff United Kingdom
Renal Unit Hôpital Femme Mère Enfant Hospices Civils de Lyon Bron France
Statistics Department Institute for Global Health University College London London United Kingdom
Citace poskytuje Crossref.org
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