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Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group
K. Schütz, D. Alecsandru, B. Grimbacher, J. Haddock, A. Bruining, G. Driessen, E. de Vries, PM. van Hagen, I. Hartmann, F. Fraioli, C. Milito, M. Mitrevski, I. Quinti, G. Serra, P. Kelleher, M. Loebinger, J. Litzman, V. Postranecka, V. Thon, J....
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2010-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- běžná variabilní imunodeficience patologie MeSH
- bronchiektazie patologie MeSH
- bronchy patologie MeSH
- dítě MeSH
- dospělí MeSH
- hrudní stěna patologie MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- počítačová rentgenová tomografie metody MeSH
- předškolní dítě MeSH
- senioři MeSH
- spirometrie metody MeSH
- syndromy imunologické nedostatečnosti patologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20 years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.
Allergy Immunology and Respiratory Medicine The Alfred Hospital Melbourne Australia
Centre for Chronic Immunodeficiency University Medical Center of Freiburg Freiburg Germany
Department of Molecular Medicine Sapienza University of Rome Rome Italy
Department of Radiology Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands
Department of Radiology University of Brescia Brescia Italy
Department of Respiratory Medicine Royal Brompton Hospital London UK
Diagnostic Radiology Hanover Medical School Hanover Germany
Dutch Cancer Institute Antoni van Leeuwenhoek Hospital The Hague The Netherlands
ESID Registry Working Party University Hospital Freiburg Freiburg Germany
Immunology Addenbrooke's Hospital Cambridge UK
Immunology and Internal Medicine Erasmus MC Rotterdam The Netherlands
Immunology Cliniques Universitaires de Bruxelles Hôpital Erasme Brussels Belgium
Immunology Papworth Hospital Cambridge UK
Immunology Section Department of Medicine Imperial College London London UK
Immunology University of Naples Federico 2 Naples Italy
Paediatric Immunology and Pulmonology University Hospitals Leuven Belgium
Paediatric Immunology Department Heartlands Hospital Birmingham Birmingham UK
Paediatric Immunology Great Ormond Street Hospital London UK
Paediatric University Hospital Cairo Egypt
Pediatrics Clinic ASST Spedali Civili Brescia Italy
Primary Immunodeficiencies Unit Pediatrics Hospital 12 Octubre Madrid Spain
Primary Immunodeficiency Unit Nuffield Department of Medicine University of Oxford Oxford UK
Radiology Addenbrooke's Hospital Cambridge UK
Radiology Heartlands Hospital Birmingham UK
Radiology IBB CNR University of Naples Federico 2 Naples Italy
Radiology Papworth Hospital Cambridge UK
Radiology Royal Free Hospital London UK
Radiology Università degli Studi di Roma La Sapienza Rome Italy
UCL Respiratory Medicine University College London London UK
Citace poskytuje Crossref.org
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