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Clustering and separation of hydrophobic nanoparticles in lipid bilayer explained by membrane mechanics

M. Daniel, J. Řezníčková, M. Handl, A. Iglič, V. Kralj-Iglič,

. 2018 ; 8 (1) : 10810. [pub] 20180717

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19045360

Grant support
15-33629A Grantová Agentura České Republiky (Grant Agency of the Czech Republic) - International
16-14758S Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic) - International
15-33629A Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic) - International
NV15-33629A MZ0 CEP Register

Small hydrophobic gold nanoparticles with diameter lower than the membrane thickness can form clusters or uniformly distribute within the hydrophobic core of the bilayer. The coexistence of two stable phases (clustered and dispersed) indicates the energy barrier between nanoparticles. We calculated the distance dependence of the membrane-mediated interaction between two adjacent nanoparticles. In our model we consider two deformation modes: the monolayer bending and the hydroxycarbon chain stretching. Existence of an energy barrier between the clustered and the separated state of nanoparticles was predicted. Variation analysis of the membrane mechanical parameters revealed that the energy barrier between two membrane embedded nanoparticles is mainly the consequence of the bending deformation and not change of the thickness of the bilayer in the vicinity of nanoparticles. It is shown, that the forces between the nanoparticles embedded in the biological membrane could be either attractive or repulsive, depending on the mutual distance between them.

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$a Daniel, Matej, $d 1978- $7 xx0029605 $u Department of Mechanics, Biomechanics and Mechatronics, Faculty of Mechanical Engineering, Czech Technical University in Prague, 16600, Prague 6, Czech Republic. matej.daniel@fs.cvut.cz.
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$a Small hydrophobic gold nanoparticles with diameter lower than the membrane thickness can form clusters or uniformly distribute within the hydrophobic core of the bilayer. The coexistence of two stable phases (clustered and dispersed) indicates the energy barrier between nanoparticles. We calculated the distance dependence of the membrane-mediated interaction between two adjacent nanoparticles. In our model we consider two deformation modes: the monolayer bending and the hydroxycarbon chain stretching. Existence of an energy barrier between the clustered and the separated state of nanoparticles was predicted. Variation analysis of the membrane mechanical parameters revealed that the energy barrier between two membrane embedded nanoparticles is mainly the consequence of the bending deformation and not change of the thickness of the bilayer in the vicinity of nanoparticles. It is shown, that the forces between the nanoparticles embedded in the biological membrane could be either attractive or repulsive, depending on the mutual distance between them.
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$a Handl, Milan $u University Hospital Motol, Charles University in Prague, 150 06, Prague 5, Czech Republic. Dubai Healthcare City, Dubai, UAE.
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