• Je něco špatně v tomto záznamu ?

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

A. Signori, G. Izquierdo, A. Lugaresi, R. Hupperts, F. Grand'Maison, P. Sola, D. Horakova, E. Havrdova, A. Prat, M. Girard, P. Duquette, C. Boz, P. Grammond, M. Terzi, B. Singhal, R. Alroughani, T. Petersen, C. Ramo, C. Oreja-Guevara, D....

. 2018 ; 24 (5) : 642-652. [pub] 20170406

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19045615

BACKGROUND: Several natural history studies on primary progressive multiple sclerosis (PPMS) patients detected a consistent heterogeneity in the rate of disability accumulation. OBJECTIVES: To identify subgroups of PPMS patients with similar longitudinal trajectories of Expanded Disability Status Scale (EDSS) over time. METHODS: All PPMS patients collected within the MSBase registry, who had their first EDSS assessment within 5 years from onset, were included in the analysis. Longitudinal EDSS scores were modeled by a latent class mixed model (LCMM), using a nonlinear function of time from onset. LCMM is an advanced statistical approach that models heterogeneity between patients by classifying them into unobserved groups showing similar characteristics. RESULTS: A total of 853 PPMS (51.7% females) from 24 countries with a mean age at onset of 42.4 years (standard deviation (SD): 10.8 years), a median baseline EDSS of 4 (interquartile range (IQR): 2.5-5.5), and 2.4 years of disease duration (SD: 1.5 years) were included. LCMM detected three different subgroups of patients with a mild ( n = 143; 16.8%), moderate ( n = 378; 44.3%), or severe ( n = 332; 38.9%) disability trajectory. The probability of reaching EDSS 6 at 10 years was 0%, 46.4%, and 81.9% respectively. CONCLUSION: Applying an LCMM modeling approach to long-term EDSS data, it is possible to identify groups of PPMS patients with different prognosis.

Amiri Hospital Kuwait City Kuwait

Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino Italy

Bombay Hospital Institute of Medical Sciences Mumbai India

Box Hill Hospital Melbourne VIC Australia Department of Medicine The University of Melbourne Melbourne VIC Australia

C Mondino National Neurological Institute Pavia Italy

Centre de Réadaptation En Déficience Physique Chaudière Appalache Levis QC Canada

Clinique Neuro Rive Sud Greenfield Park QC Canada

Cliniques Universitaires Saint Luc Brussels Belgium

Craigavon Area Hospital Craigavon UK

Department NEUROFARBA Section Neuroscience University of Florence Florence Italy

Department of Basic Medical Sciences Neuroscience and Sense Organs University of Bari Bari Italy

Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum University of Bologna Italy IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy

Department of Health Sciences Section of Biostatistics University of Genoa Genova Italy

Department of Medicine The University of Melbourne Melbourne VIC Australia

Department of Neurology and Center of Clinical Neuroscience 1st Faculty of Medicine Charles University and General University Hospital Prague Prague Czech Republic

Department of Neurology Golestan University of Medical Sciences Gorgan Iran Golestan Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Flinders University and Medical Centre Adelaide SA Australia

Golestan Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Groene Hart Ziekenhuis Gouda The Netherlands

Hôpital Notre Dame Montreal QC Canada

Hospital Clinico San Carlos Madrid Spain

Hospital de Galdakao Usansolo Galdakao Spain

Hospital Germans Trias i Pujol Badalona Spain

Hospital São João Porto Portugal

Hospital Universitario Virgen de Valme Seville Spain

Hospital Universitario Virgen Macarena Sevilla Spain

Hunter Medical Research Institute The University of Newcastle Newcastle NSW Australia

Isfahan University of Medical Sciences Isfahan Iran

Kommunehospitalet Aarhus Denmark

KTU Medical Faculty Farabi Hospital Trabzon Turkey

Medical Faculty Ondokuz Mayis University Samsun Turkey

Nuovo Ospedale Civile S Agostino Estense Modena Italy

Ospedali Riuniti di Salerno Salerno Italy

Royal Hobart Hospital Hobart TAS Australia

University of Parma Parma Italy

UOC Neurologia Azienda Sanitaria Unica Regionale Marche Macerata Italy

Zuyderland Ziekenhuis Sittard The Netherlands

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19045615
003      
CZ-PrNML
005      
20200116090717.0
007      
ta
008      
200109s2018 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1177/1352458517703800 $2 doi
035    __
$a (PubMed)28382837
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Signori, Alessio $u Department of Health Sciences (DISSAL), Section of Biostatistics, University of Genoa, Genova, Italy.
245    10
$a Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis / $c A. Signori, G. Izquierdo, A. Lugaresi, R. Hupperts, F. Grand'Maison, P. Sola, D. Horakova, E. Havrdova, A. Prat, M. Girard, P. Duquette, C. Boz, P. Grammond, M. Terzi, B. Singhal, R. Alroughani, T. Petersen, C. Ramo, C. Oreja-Guevara, D. Spitaleri, V. Shaygannejad, H. Butzkueven, T. Kalincik, V. Jokubaitis, M. Slee, R. Fernandez Bolaños, JL. Sanchez-Menoyo, E. Pucci, F. Granella, J. Lechner-Scott, G. Iuliano, S. Hughes, R. Bergamaschi, B. Taylor, F. Verheul, M. Edite Rio, MP. Amato, SA. Sajedi, N. Majdinasab, V. Van Pesch, MP. Sormani, M. Trojano,
520    9_
$a BACKGROUND: Several natural history studies on primary progressive multiple sclerosis (PPMS) patients detected a consistent heterogeneity in the rate of disability accumulation. OBJECTIVES: To identify subgroups of PPMS patients with similar longitudinal trajectories of Expanded Disability Status Scale (EDSS) over time. METHODS: All PPMS patients collected within the MSBase registry, who had their first EDSS assessment within 5 years from onset, were included in the analysis. Longitudinal EDSS scores were modeled by a latent class mixed model (LCMM), using a nonlinear function of time from onset. LCMM is an advanced statistical approach that models heterogeneity between patients by classifying them into unobserved groups showing similar characteristics. RESULTS: A total of 853 PPMS (51.7% females) from 24 countries with a mean age at onset of 42.4 years (standard deviation (SD): 10.8 years), a median baseline EDSS of 4 (interquartile range (IQR): 2.5-5.5), and 2.4 years of disease duration (SD: 1.5 years) were included. LCMM detected three different subgroups of patients with a mild ( n = 143; 16.8%), moderate ( n = 378; 44.3%), or severe ( n = 332; 38.9%) disability trajectory. The probability of reaching EDSS 6 at 10 years was 0%, 46.4%, and 81.9% respectively. CONCLUSION: Applying an LCMM modeling approach to long-term EDSS data, it is possible to identify groups of PPMS patients with different prognosis.
650    _2
$a dospělí $7 D000328
650    _2
$a věkové faktory $7 D000367
650    _2
$a Bayesova věta $7 D001499
650    _2
$a opožděná diagnóza $7 D057210
650    12
$a posuzování pracovní neschopnosti $7 D004185
650    _2
$a postižení $7 D006233
650    12
$a progrese nemoci $7 D018450
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    12
$a analýza latentních tříd $7 D000077272
650    _2
$a longitudinální studie $7 D008137
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a chronicko-progresivní roztroušená skleróza $x diagnóza $x patologie $7 D020528
650    _2
$a prognóza $7 D011379
650    _2
$a prospektivní studie $7 D011446
650    12
$a registrace $7 D012042
650    _2
$a sexuální faktory $7 D012737
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Izquierdo, Guillermo $u Hospital Universitario Virgen Macarena, Sevilla, Spain.
700    1_
$a Lugaresi, Alessandra $u Department of Biomedical and Neuromotor Sciences(DIBINEM), Alma Mater Studiorum, University of Bologna, Italy/IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
700    1_
$a Hupperts, Raymond $u Zuyderland Ziekenhuis, Sittard, The Netherlands.
700    1_
$a Grand'Maison, Francois $u Clinique Neuro Rive-Sud, Greenfield Park, QC, Canada.
700    1_
$a Sola, Patrizia $u Nuovo Ospedale Civile S. Agostino-Estense, Modena, Italy.
700    1_
$a Horakova, Dana $u Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
700    1_
$a Havrdova, Eva $u Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
700    1_
$a Prat, Alexandre $u Hôpital Notre-Dame, Montreal, QC, Canada.
700    1_
$a Girard, Marc $u Hôpital Notre-Dame, Montreal, QC, Canada.
700    1_
$a Duquette, Pierre $u Hôpital Notre-Dame, Montreal, QC, Canada.
700    1_
$a Boz, Cavit $u KTU Medical Faculty Farabi Hospital, Trabzon, Turkey.
700    1_
$a Grammond, Pierre $u Centre de Réadaptation En Déficience Physique Chaudière-Appalache, Levis, QC, Canada.
700    1_
$a Terzi, Murat $u Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.
700    1_
$a Singhal, Bhim $u Bombay Hospital Institute of Medical Sciences (BHIMS), Mumbai, India.
700    1_
$a Alroughani, Raed $u Amiri Hospital, Kuwait City, Kuwait.
700    1_
$a Petersen, Thor $u Kommunehospitalet, Aarhus, Denmark.
700    1_
$a Ramo, Cristina $u Hospital Germans Trias i Pujol, Badalona, Spain.
700    1_
$a Oreja-Guevara, Celia $u Hospital Clinico San Carlos, Madrid, Spain.
700    1_
$a Spitaleri, Daniele $u Azienda Ospedaliera di Rilievo Nazionale, San Giuseppe Moscati, Avellino, Italy.
700    1_
$a Shaygannejad, Vahid $u Isfahan University of Medical Sciences, Isfahan, Iran.
700    1_
$a Butzkueven, Helmut $u Box Hill Hospital, Melbourne, VIC, Australia/Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
700    1_
$a Kalincik, Tomas $u Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
700    1_
$a Jokubaitis, Vilija $u Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia.
700    1_
$a Slee, Mark $u Flinders University and Medical Centre, Adelaide, SA, Australia.
700    1_
$a Fernandez Bolaños, Ricardo $u Hospital Universitario Virgen de Valme, Seville, Spain.
700    1_
$a Sanchez-Menoyo, Jose Luis $u Hospital de Galdakao-Usansolo, Galdakao, Spain.
700    1_
$a Pucci, Eugenio $u UOC Neurologia, Azienda Sanitaria Unica Regionale Marche, Macerata, Italy.
700    1_
$a Granella, Franco $u University of Parma, Parma, Italy.
700    1_
$a Lechner-Scott, Jeannette $u Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.
700    1_
$a Iuliano, Gerardo $u Ospedali Riuniti di Salerno, Salerno, Italy.
700    1_
$a Hughes, Stella $u Craigavon Area Hospital, Craigavon, UK.
700    1_
$a Bergamaschi, Roberto $u C. Mondino National Neurological Institute, Pavia, Italy.
700    1_
$a Taylor, Bruce $u Royal Hobart Hospital, Hobart, TAS, Australia.
700    1_
$a Verheul, Freek $u Groene Hart Ziekenhuis, Gouda, The Netherlands.
700    1_
$a Edite Rio, Maria $u Hospital São João, Porto, Portugal.
700    1_
$a Amato, Maria Pia $u Department NEUROFARBA, Section Neuroscience, University of Florence, Florence, Italy.
700    1_
$a Sajedi, Seyed Aidin $u Department of Neurology, Golestan University of Medical Sciences, Gorgan, Iran/Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
700    1_
$a Majdinasab, Nastaran $u Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
700    1_
$a Van Pesch, Vincent $u Cliniques Universitaires Saint-Luc, Brussels, Belgium.
700    1_
$a Sormani, Maria Pia $u Department of Health Sciences (DISSAL), Section of Biostatistics, University of Genoa, Genova, Italy.
700    1_
$a Trojano, Maria $u Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy.
773    0_
$w MED00006389 $t Multiple sclerosis (Houndmills, Basingstoke, England) $x 1477-0970 $g Roč. 24, č. 5 (2018), s. 642-652
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28382837 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200109 $b ABA008
991    __
$a 20200116091051 $b ABA008
999    __
$a ok $b bmc $g 1483883 $s 1084288
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 24 $c 5 $d 642-652 $e 20170406 $i 1477-0970 $m Multiple sclerosis $n Mult Scler $x MED00006389
LZP    __
$a Pubmed-20200109

Najít záznam

Citační ukazatele

Možnosti archivace