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Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes
M. Tschuschke, I. Kocherova, A. Bryja, P. Mozdziak, A. Angelova Volponi, K. Janowicz, R. Sibiak, H. Piotrowska-Kempisty, D. Iżycki, D. Bukowska, P. Antosik, JA. Shibli, M. Dyszkiewicz-Konwińska, B. Kempisty,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
NLK
Free Medical Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2019-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Health & Medicine (ProQuest)
od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
32041096
DOI
10.3390/jcm9020436
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Exosomes are a heterogenous subpopulation of extracellular vesicles 30-150 nm in range and of endosome-derived origin. We explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. Different isolation techniques and specificities of exosomes from different tissues and cells are also discussed. Despite more than 30 years of research that followed their definition and indicated their important role in cellular physiology, the exosome biology is still in its infancy with rapidly growing interest. The reasons for the rapid increase in interest with respect to exosome biology is because they provide means of intercellular communication and transmission of macromolecules between cells, with a potential role in the development of diseases. Moreover, they have been investigated as prognostic biomarkers, with a potential for further development as diagnostic tools for neurodegenerative diseases and cancer. The interest grows further with the fact that exosomes were reported as useful vectors for drugs.
Department of Anatomy Poznan University of Medical Sciences 60 781 Poznań Poland
Department of Cancer Immunology Poznan University of Medical Sciences 61 866 Poznań Poland
Department of Toxicology Poznan University of Medical Sciences 61 131 Poznań Poland
Department of Veterinary Surgery Nicolaus Copernicus University in Torun 87 100 Toruń Poland
Physiology Graduate Program North Carolina State University Raleigh NC 27695 USA
Citace poskytuje Crossref.org
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- $a Exosomes are a heterogenous subpopulation of extracellular vesicles 30-150 nm in range and of endosome-derived origin. We explored the exosome formation through different systems, including the endosomal sorting complex required for transport (ESCRT) and ESCRT-independent system, looking at the mechanisms of release. Different isolation techniques and specificities of exosomes from different tissues and cells are also discussed. Despite more than 30 years of research that followed their definition and indicated their important role in cellular physiology, the exosome biology is still in its infancy with rapidly growing interest. The reasons for the rapid increase in interest with respect to exosome biology is because they provide means of intercellular communication and transmission of macromolecules between cells, with a potential role in the development of diseases. Moreover, they have been investigated as prognostic biomarkers, with a potential for further development as diagnostic tools for neurodegenerative diseases and cancer. The interest grows further with the fact that exosomes were reported as useful vectors for drugs.
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