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Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers
F. Qian, MA. Rookus, G. Leslie, HA. Risch, MH. Greene, CM. Aalfs, MA. Adank, J. Adlard, BA. Agnarsson, M. Ahmed, K. Aittomäki, IL. Andrulis, N. Arnold, BK. Arun, MGEM. Ausems, J. Azzollini, D. Barrowdale, J. Barwell, J. Benitez, K. Białkowska, V....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
Grantová podpora
P30 CA051008
NCI NIH HHS - United States
UL1 TR001863
NCATS NIH HHS - United States
R03 CA130065
NCI NIH HHS - United States
C5047/A8384
Cancer Research UK - United Kingdom
C1287/A 10710
Cancer Research UK - United Kingdom
U19 CA148065
NCI NIH HHS - United States
R01 CA228198
NCI NIH HHS - United States
C1281/A12014
Cancer Research UK - United Kingdom
R25 CA112486
NCI NIH HHS - United States
P30 CA008748
NCI NIH HHS - United States
R01 CA149429
NCI NIH HHS - United States
R01 CA063682
NCI NIH HHS - United States
UL1 TR000124
NCATS NIH HHS - United States
U01 CA161032
NCI NIH HHS - United States
U19 CA148112
NCI NIH HHS - United States
P20 CA233307
NCI NIH HHS - United States
R01 CA142996
NCI NIH HHS - United States
CRN-87521
CIHR - Canada
R01 CA140323
NCI NIH HHS - United States
R01 CA214545
NCI NIH HHS - United States
P30 CA168524
NCI NIH HHS - United States
MR/P012930/1
Medical Research Council - United Kingdom
C12292
Cancer Research UK (CRUK) - International
U10 CA180822
NCI NIH HHS - United States
C5047/A15007
Cancer Research UK - United Kingdom
A11174
Cancer Research UK (CRUK) - International
A20861
Cancer Research UK (CRUK) - International
RC4 CA153828
NCI NIH HHS - United States
UM1 CA164920
NCI NIH HHS - United States
U10 CA180868
NCI NIH HHS - United States
C8197/A16565
Cancer Research UK - United Kingdom
10118
Cancer Research UK - United Kingdom
U19 CA148537
NCI NIH HHS - United States
NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- geny BRCA1 * MeSH
- geny BRCA2 * MeSH
- heterozygot * MeSH
- index tělesné hmotnosti * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mendelovská randomizace * MeSH
- menopauza MeSH
- mutace * MeSH
- nádory vaječníků etiologie genetika MeSH
- proporcionální rizikové modely MeSH
- senioři MeSH
- tělesná výška * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
BACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS) using 586 height-associated variants and a BMI genetic score (BMI-GS) using 93 BMI-associated variants. Associations were assessed using weighted Cox models. RESULTS: Observed height was not associated with ovarian cancer risk (hazard ratio [HR]: 1.07 per 10-cm increase in height, 95% confidence interval [CI]: 0.94-1.23). Height-GS showed similar results (HR = 1.02, 95% CI: 0.85-1.23). Higher BMI was significantly associated with increased risk in premenopausal women with HR = 1.25 (95% CI: 1.06-1.48) and HR = 1.59 (95% CI: 1.08-2.33) per 5-kg/m2 increase in observed and genetically determined BMI, respectively. No association was found for postmenopausal women. Interaction between menopausal status and BMI was significant (Pinteraction < 0.05). CONCLUSION: Our observation of a positive association between BMI and ovarian cancer risk in premenopausal BRCA1/2 mutation carriers is consistent with findings in the general population.
Cancer Genetics and Prevention Program University of California San Francisco San Francisco CA USA
Cancer Risk and Prevention Clinic Dana Farber Cancer Institute Boston MA USA
Center for Clinical Cancer Genetics The University of Chicago Chicago IL USA
Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Centre for Medical Genetics Ghent University Gent Belgium
Chronic Disease Epidemiology Yale School of Public Health New Haven CT USA
Clinical Cancer Genomics City of Hope Duarte CA USA
Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London UK
Clinical Genetics Karolinska Institutet Stockholm Sweden
Département de Génétique CHU de Grenoble Grenoble France
Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston TX USA
Department of Cancer Biology and Genetics The Ohio State University Columbus OH USA
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Genetics Amsterdam UMC Location AMC Amsterdam The Netherlands
Department of Clinical Genetics Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam The Netherlands
Department of Clinical Genetics Erasmus University Medical Center Rotterdam The Netherlands
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia PA USA
Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland
Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands
Department of Clinical Genetics Odense University Hospital Odence C Denmark
Department of Epidemiology Mailman School of Public Health Columbia University New York NY USA
Department of Epidemiology The Netherlands Cancer Institute Amsterdam The Netherlands
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Genetics University of Pretoria Arcadia South Africa
Department of Gynecology and Obstetrics Ludwig Maximilian University of Munich Munich Germany
Department of Human Genetics Radboud University Medical Center Nijmegen The Netherlands
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA
Department of Medical Oncology Beth Israel Deaconess Medical Center Boston MA USA
Department of Medical Oncology CHU Dupuytren Limoges France
Department of Medicine Huntsman Cancer Institute Salt Lake City UT USA
Department of Medicine University of Chicago Chicago IL USA
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Molecular Medicine University La Sapienza Rome Italy
Department of OB GYN and Comprehensive Cancer Center Medical University of Vienna Vienna Austria
Department of Oncology Lund University and Skåne University Hospital Lund Sweden
Department of Pathology and Laboratory Medicine Kansas University Medical Center Kansas City KS USA
Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA USA
Departments of Pediatrics and Medicine Columbia University New York NY USA
Genetic Epidemiology of Cancer team Inserm U900 Paris France Institut Curie Paris France
Genome Diagnostics Program IFOM the FIRC Institute of Molecular Oncology Milan Italy
Harvard T H Chan School of Public Health Boston MA USA Dana Farber Cancer Institute Boston MA USA
Human Cancer Genetics Programme Spanish National Cancer Research Centre Madrid Spain
Immunology and Molecular Oncology Unit Veneto Institute of Oncology IOV IRCCS Padua Italy
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Institute of Cell and Molecular Pathology Hannover Medical School Hannover Germany
Leicestershire Clinical Genetics Service University Hospitals of Leicester NHS Trust Leicester UK
Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA
Molecular Diagnostic Unit Hereditary Cancer Program ICO IDIBELL CIBERONC Barcelona Spain
Molecular Genetics of Breast Cancer German Cancer Research Center Heidelberg Germany
N N Petrov Institute of Oncology St Petersburg Russia
North East Thames Regional Genetics Service Great Ormond Street Hospital London UK
Nottingham Clinical Genetics Service Nottingham University Hospitals NHS Trust Nottingham UK
NRG Oncology Statistics and Data Management Center Roswell Park Cancer Institute Buffalo NY USA
Oncogenetics Team The Institute of Cancer Research and Royal Marsden NHS Foundation Trust London UK
Oxford Regional Genetics Service Churchill Hospital Oxford UK
Section of Molecular Genetics Dept of Laboratory Medicine University Hospital of Pisa Pisa Italy
Service de Génétique CHU de Besançon Besançon France
Service de Génétique Institut Curie Paris France
The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center Ramat Gan Israel
Unité d'Oncogénétique ICO Centre René Gauducheau Saint Herblain France
Unité de Prévention et d'Epidémiologie Génétique Centre Léon Bérard Lyon France
Wessex Clinical Genetics Service University Hospitals Southampton NHS Trust Southampton UK
Wexner Medical Center The Ohio State University Columbus OH USA
Yorkshire Regional Genetics Service Chapel Allerton Hospital Leeds UK
Citace poskytuje Crossref.org
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- $a Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers / $c F. Qian, MA. Rookus, G. Leslie, HA. Risch, MH. Greene, CM. Aalfs, MA. Adank, J. Adlard, BA. Agnarsson, M. Ahmed, K. Aittomäki, IL. Andrulis, N. Arnold, BK. Arun, MGEM. Ausems, J. Azzollini, D. Barrowdale, J. Barwell, J. Benitez, K. Białkowska, V. Bonadona, J. Borde, A. Borg, AR. Bradbury, J. Brunet, SS. Buys, T. Caldés, MA. Caligo, I. Campbell, J. Carter, J. Chiquette, WK. Chung, KBM. Claes, JM. Collée, MA. Collonge-Rame, FJ. Couch, MB. Daly, C. Delnatte, O. Diez, SM. Domchek, CM. Dorfling, J. Eason, DF. Easton, R. Eeles, C. Engel, DG. Evans, L. Faivre, L. Feliubadaló, L. Foretova, E. Friedman, D. Frost, PA. Ganz, J. Garber, V. Garcia-Barberan, A. Gehrig, G. Glendon, AK. Godwin, EB. Gómez Garcia, U. Hamann, J. Hauke, JL. Hopper, PJ. Hulick, EN. Imyanitov, C. Isaacs, L. Izatt, A. Jakubowska, R. Janavicius, EM. John, BY. Karlan, CM. Kets, Y. Laitman, C. Lázaro, D. Leroux, J. Lester, F. Lesueur, JT. Loud, J. Lubiński, A. Łukomska, L. McGuffog, N. Mebirouk, HEJ. Meijers-Heijboer, A. Meindl, A. Miller, M. Montagna, TM. Mooij, E. Mouret-Fourme, KL. Nathanson, B. Nehoray, SL. Neuhausen, H. Nevanlinna, FC. Nielsen, K. Offit, E. Olah, KR. Ong, JC. Oosterwijk, L. Ottini, MT. Parsons, P. Peterlongo, G. Pfeiler, N. Pradhan, P. Radice, SJ. Ramus, J. Rantala, G. Rennert, M. Robson, GC. Rodriguez, R. Salani, MT. Scheuner, RK. Schmutzler, PD. Shah, LE. Side, J. Simard, CF. Singer, D. Steinemann, D. Stoppa-Lyonnet, YY. Tan, MR. Teixeira, MB. Terry, M. Thomassen, M. Tischkowitz, S. Tognazzo, AE. Toland, N. Tung, CJ. van Asperen, K. van Engelen, EJ. van Rensburg, L. Venat-Bouvet, J. Vierstraete, G. Wagner, L. Walker, JN. Weitzel, D. Yannoukakos, KConFab Investigators, HEBON Investigators, GEMO Study Collaborators, EMBRACE Collaborators, AC. Antoniou, DE. Goldgar, OI. Olopade, G. Chenevix-Trench, TR. Rebbeck, D. Huo, CIMBA,
- 520 9_
- $a BACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS) using 586 height-associated variants and a BMI genetic score (BMI-GS) using 93 BMI-associated variants. Associations were assessed using weighted Cox models. RESULTS: Observed height was not associated with ovarian cancer risk (hazard ratio [HR]: 1.07 per 10-cm increase in height, 95% confidence interval [CI]: 0.94-1.23). Height-GS showed similar results (HR = 1.02, 95% CI: 0.85-1.23). Higher BMI was significantly associated with increased risk in premenopausal women with HR = 1.25 (95% CI: 1.06-1.48) and HR = 1.59 (95% CI: 1.08-2.33) per 5-kg/m2 increase in observed and genetically determined BMI, respectively. No association was found for postmenopausal women. Interaction between menopausal status and BMI was significant (Pinteraction < 0.05). CONCLUSION: Our observation of a positive association between BMI and ovarian cancer risk in premenopausal BRCA1/2 mutation carriers is consistent with findings in the general population.
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- 700 1_
- $a Rookus, Matti A $u Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
- 700 1_
- $a Leslie, Goska $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Risch, Harvey A $u Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
- 700 1_
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- 700 1_
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- 700 1_
- $a Adank, Muriel A $u Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
- 700 1_
- $a Adlard, Julian $u Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
- 700 1_
- $a Agnarsson, Bjarni A $u Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. School of Medicine, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Ahmed, Munaza $u North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, UK.
- 700 1_
- $a Aittomäki, Kristiina $u Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Andrulis, Irene L $u Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Barrowdale, Daniel $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Barwell, Julian $u Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.
- 700 1_
- $a Benitez, Javier $u Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
- 700 1_
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- 700 1_
- $a Bonadona, Valérie $u Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
- 700 1_
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- 700 1_
- $a Jakubowska, Anna $u Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a Janavicius, Ramunas $u Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. State Research Institute, Innovative Medicine Center, Vilnius, CA, Lithuania.
- 700 1_
- $a John, Esther M $u Department of Medicine, Division of Oncology, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
- 700 1_
- $a Karlan, Beth Y $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 700 1_
- $a Kets, Carolien M $u Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
- 700 1_
- $a Laitman, Yael $u The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 700 1_
- $a Lázaro, Conxi $u Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain.
- 700 1_
- $a Leroux, Dominique $u Département de Génétique, CHU de Grenoble, Grenoble, France.
- 700 1_
- $a Lester, Jenny $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 700 1_
- $a Lesueur, Fabienne $u Genetic Epidemiology of Cancer team, Inserm U900, Paris, France. Institut Curie, Paris, France.
- 700 1_
- $a Loud, Jennifer T $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Lubiński, Jan $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a Łukomska, Alicja $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a McGuffog, Lesley $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
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- 700 1_
- $a Meijers-Heijboer, Hanne E J $u Department of Clinical Genetics, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Service de Génétique, Institut Curie, Paris, France. Department of Tumour Biology, INSERM U830, Paris, France. Université Paris Descartes, Paris, France.
- 700 1_
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- 700 1_
- $a Teixeira, Manuel R $u Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Toland, Amanda E $u Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA.
- 700 1_
- $a Tung, Nadine $u Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
- 700 1_
- $a van Asperen, Christi J $u Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a van Engelen, Klaartje $u Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
- 700 1_
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- 700 1_
- $a Venat-Bouvet, Laurence $u Department of Medical Oncology, CHU Dupuytren, Limoges, France.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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