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Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
P. Stojkova, P. Spidlova, J. Stulik,
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
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- MeSH
- Bacterial Proteins chemistry genetics metabolism MeSH
- DNA, Bacterial metabolism MeSH
- DNA-Binding Proteins chemistry genetics metabolism MeSH
- DNA chemistry MeSH
- Protein Processing, Post-Translational MeSH
- Gene Expression Regulation, Bacterial physiology MeSH
- Protein Binding MeSH
- Virulence genetics physiology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria. The best-known nucleoid-associated proteins, such as HU, FIS, H-NS, and IHF, are often discussed. The most important findings in research concerning HU protein are described in this mini review. Its roles in DNA compaction, shape modulation, and negative supercoiling induction have been studied intensively. HU protein regulates bacteria survival, growth, SOS response, virulence genes expression, cell division, and many other cell processes. Elucidating the mechanism of HU protein action has been the subject of many research projects. This mini review provides a comprehensive overview of the HU protein.
References provided by Crossref.org
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