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Exposure to sodium salicylate disrupts VGLUT3 expression in cochlear inner hair cells and contributes to tinnitus
W. Zhang, Z. Peng, S. Yu, Q. L. Song, T. F. Qu, K. Liu, S. S. Gong
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Anti-Inflammatory Agents, Non-Steroidal adverse effects MeSH
- Inferior Colliculi drug effects metabolism MeSH
- Cochlear Nucleus drug effects metabolism MeSH
- Rats, Wistar MeSH
- Sodium Salicylate adverse effects MeSH
- Auditory Threshold drug effects MeSH
- Tinnitus chemically induced MeSH
- Vesicular Glutamate Transport Proteins metabolism MeSH
- Hair Cells, Auditory, Inner drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
To examine whether exposure to sodium salicylate disrupts expression of vesicular glutamate transporter 3 (VGLUT3) and whether the alteration in expression corresponds to increased risk for tinnitus. Rats were treated with saline (control) or sodium salicylate (treated) Rats were examined for tinnitus by monitoring gap-pre-pulse inhibition of the acoustic startle reflex (GPIAS). Auditory brainstem response (ABR) was applied to evaluate hearing function after treatment. Rats were sacrificed after injection to obtain the cochlea, cochlear nucleus (CN), and inferior colliculus (IC) for examination of VGLUT3 expression. No significant differences in hearing thresholds between groups were identified (p>0.05). Tinnitus in sodium salicylate-treated rats was confirmed by GPIAS. VGLUT3 encoded by solute carrier family 17 members 8 (SLC17a8) expression was significantly increased in inner hair cells (IHCs) of the cochlea in treated animals, compared with controls (p<0.01). No significant differences in VGLUT3 expression between groups were found for the cochlear nucleus (CN) or IC (p>0.05). Exposure to sodium salicylate may disrupt SLC17a8 expression in IHCs, leading to alterations that correspond to tinnitus in rats. However, the CN and IC are unaffected by exposure to sodium salicylate, suggesting that enhancement of VGLUT3 expression in IHCs may contribute to the pathogenesis of tinnitus.
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Literatura
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